CRISPR knock out of programmed cell death protein 1 enhances anti-tumor activity of cytotoxic T lymphocytes

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that functions to attenuate T cell activation. In this study, we knocked out (KO) PD-1 in cytotoxic T lymphocytes (CTLs) using CRISPR-Cas9 system to evaluate its effect on the anti-tumor activity of the CTLs against multiple mye...

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Detalles Bibliográficos
Autores principales: Zhao, Zhilong, Shi, Long, Zhang, Wei, Han, Jinsheng, Zhang, Shaohui, Fu, Zexian, Cai, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797044/
https://www.ncbi.nlm.nih.gov/pubmed/29435173
http://dx.doi.org/10.18632/oncotarget.23730

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