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First identification of marine diatoms with anti-tuberculosis activity
Marine microalgae are considered a potentially new and valuable source of biologically active compounds for applications in several biotechnology sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797112/ https://www.ncbi.nlm.nih.gov/pubmed/29396507 http://dx.doi.org/10.1038/s41598-018-20611-x |
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author | Lauritano, Chiara Martín, Jesús de la Cruz, Mercedes Reyes, Fernando Romano, Giovanna Ianora, Adrianna |
author_facet | Lauritano, Chiara Martín, Jesús de la Cruz, Mercedes Reyes, Fernando Romano, Giovanna Ianora, Adrianna |
author_sort | Lauritano, Chiara |
collection | PubMed |
description | Marine microalgae are considered a potentially new and valuable source of biologically active compounds for applications in several biotechnology sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems associated with the over-utilization of marine resources and the use of destructive collection practices. Considering the increasing rate of antibiotic-resistance bacteria and infections by fungi, 46 microalgae have been screened in this study for possible antibacterial and antifungal activities. Two different extraction methods have been used in order to increase the probability of finding positive hits. In particular, we screened microalgae in both control and nutrient stress conditions. We also tested different strains for 7 species in order to study potentially different bioactivities due to strain diversity. Results showed that extracts of two diatoms, Skeletonema costatum and Chaetoceros pseudocurvisetus, had anti-tuberculosis activity and were active only when cultured in the control and phosphate-starvation conditions, while the nitrogen starvation condition showed no activity. In addition, we tested both the organic and water extracts and found that only the organic extracts for both diatoms were active. The organic extracts of these two diatom species were not toxic on normal human cell lines. |
format | Online Article Text |
id | pubmed-5797112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57971122018-02-12 First identification of marine diatoms with anti-tuberculosis activity Lauritano, Chiara Martín, Jesús de la Cruz, Mercedes Reyes, Fernando Romano, Giovanna Ianora, Adrianna Sci Rep Article Marine microalgae are considered a potentially new and valuable source of biologically active compounds for applications in several biotechnology sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems associated with the over-utilization of marine resources and the use of destructive collection practices. Considering the increasing rate of antibiotic-resistance bacteria and infections by fungi, 46 microalgae have been screened in this study for possible antibacterial and antifungal activities. Two different extraction methods have been used in order to increase the probability of finding positive hits. In particular, we screened microalgae in both control and nutrient stress conditions. We also tested different strains for 7 species in order to study potentially different bioactivities due to strain diversity. Results showed that extracts of two diatoms, Skeletonema costatum and Chaetoceros pseudocurvisetus, had anti-tuberculosis activity and were active only when cultured in the control and phosphate-starvation conditions, while the nitrogen starvation condition showed no activity. In addition, we tested both the organic and water extracts and found that only the organic extracts for both diatoms were active. The organic extracts of these two diatom species were not toxic on normal human cell lines. Nature Publishing Group UK 2018-02-02 /pmc/articles/PMC5797112/ /pubmed/29396507 http://dx.doi.org/10.1038/s41598-018-20611-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lauritano, Chiara Martín, Jesús de la Cruz, Mercedes Reyes, Fernando Romano, Giovanna Ianora, Adrianna First identification of marine diatoms with anti-tuberculosis activity |
title | First identification of marine diatoms with anti-tuberculosis activity |
title_full | First identification of marine diatoms with anti-tuberculosis activity |
title_fullStr | First identification of marine diatoms with anti-tuberculosis activity |
title_full_unstemmed | First identification of marine diatoms with anti-tuberculosis activity |
title_short | First identification of marine diatoms with anti-tuberculosis activity |
title_sort | first identification of marine diatoms with anti-tuberculosis activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797112/ https://www.ncbi.nlm.nih.gov/pubmed/29396507 http://dx.doi.org/10.1038/s41598-018-20611-x |
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