Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect

Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR). Luciferase reporter assays and in silico docking studies s...

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Detalles Bibliográficos
Autores principales: Tamura, Satoru, Okada, Maiko, Kato, Shigeaki, Shinoda, Yasuharu, Shioda, Norifumi, Fukunaga, Kohji, Ui-Tei, Kumiko, Ueda, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797171/
https://www.ncbi.nlm.nih.gov/pubmed/29396543
http://dx.doi.org/10.1038/s41598-018-20663-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797171/
https://www.ncbi.nlm.nih.gov/pubmed/29396543
http://dx.doi.org/10.1038/s41598-018-20663-z

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