Cargando…

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect

Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR). Luciferase reporter assays and in silico docking studies s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tamura, Satoru, Okada, Maiko, Kato, Shigeaki, Shinoda, Yasuharu, Shioda, Norifumi, Fukunaga, Kohji, Ui-Tei, Kumiko, Ueda, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797171/ https://www.ncbi.nlm.nih.gov/pubmed/29396543 http://dx.doi.org/10.1038/s41598-018-20663-z

Ejemplares similares

A convergent total synthesis of ouabagenin
por: Mukai, Ken, et al.
Publicado: (2015)

Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogues
por: Renata, Hans, et al.
Publicado: (2015)

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA(A) Receptor
por: Yabuki, Yasushi, et al.
Publicado: (2020)

Physiological and Pathological Roles of CaMKII-PP1 Signaling in the Brain
por: Shioda, Norifumi, et al.
Publicado: (2017)

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
por: Zhou, Enchen, et al.
Publicado: (2023)

PT562. Alzheimer disease therapeutics candidate, SAK3 improves the cognitive functions through inhibition of amyloid beta accumulation in APP23 mice.
por: Izumi, ○Hisanao, et al.
Publicado: (2016)

Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
por: Ui-Tei, Kumiko
Publicado: (2013)

Is the Efficiency of RNA Silencing Evolutionarily Regulated?
por: Ui-Tei, Kumiko
Publicado: (2016)

Inhibition of LXRα/SREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule
por: Wang, Miao, et al.
Publicado: (2013)

Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress
por: Wang, Yifei, et al.
Publicado: (2021)

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
por: Cho, Kumsun, et al.
Publicado: (2015)

SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome
por: Yamaguchi, Kouya, et al.
Publicado: (2018)

Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway
por: Zhu, Wenqiang, et al.
Publicado: (2022)

Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin
por: Matsuo, Kazuya, et al.
Publicado: (2022)

siRNA Design Software for a Target Gene-Specific RNA Interference
por: Naito, Yuki, et al.
Publicado: (2012)

Mutual Regulation of RNA Silencing and the IFN Response as an Antiviral Defense System in Mammalian Cells
por: Takahashi, Tomoko, et al.
Publicado: (2020)

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling
por: Izumi, Hisanao, et al.
Publicado: (2020)

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia
por: Kratzer, Adelheid, et al.
Publicado: (2009)

Metabolic Modeling Combined With Machine Learning Integrates Longitudinal Data and Identifies the Origin of LXR-Induced Hepatic Steatosis
por: van Riel, Natal A. W., et al.
Publicado: (2021)

α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss
por: Guo, Qingyun, et al.
Publicado: (2023)

Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis
por: Feng, Ke, et al.
Publicado: (2021)

LXRα and LXRβ Nuclear Receptors Evolved in the Common Ancestor of Gnathostomes
por: Fonseca, Elza, et al.
Publicado: (2017)

CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart
por: Lu, Ying-Mei, et al.
Publicado: (2011)

Essential Notes Regarding the Design of Functional siRNAs for Efficient Mammalian RNAi
por: Ui-Tei, Kumiko, et al.
Publicado: (2006)

Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex
por: Munakata, Fusako, et al.
Publicado: (2021)

Modulation of MicroRNA Processing by Dicer via Its Associated dsRNA Binding Proteins
por: Yoshida, Toyotaka, et al.
Publicado: (2021)

The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects
por: Kobayashi, Yoshiaki, et al.
Publicado: (2022)

Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice
por: Moriguchi, Shigeki, et al.
Publicado: (2013)

Correction: Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice
por: Moriguchi, Shigeki, et al.
Publicado: (2014)

Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling
por: Xie, Yang, et al.
Publicado: (2023)

Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches
por: Chen, Meimei, et al.
Publicado: (2018)

Osteopoikilosis Occurring in the Skull
por: Okada, Asuka, et al.
Publicado: (2016)

Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain
por: Yabuki, Yasushi, et al.
Publicado: (2020)

miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
por: Vinod, Manjula, et al.
Publicado: (2014)

Thermodynamic Control of Small RNA-Mediated Gene Silencing
por: Ui-Tei, Kumiko, et al.
Publicado: (2012)

E-Cadherin Is Transcriptionally Activated via Suppression of ZEB1 Transcriptional Repressor by Small RNA-Mediated Gene Silencing
por: Mazda, Minami, et al.
Publicado: (2011)

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect
por: Naito, Yuki, et al.
Publicado: (2009)

RNAi induced in mammalian and Drosophila cells via transfection of dimers and trimers of small interfering RNA
por: Ui-Tei, Kumiko, et al.
Publicado: (2005)

A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency
por: Kume, Hideaki, et al.
Publicado: (2014)

Fluctuation of Global Gene Expression by Endogenous miRNA Response to the Introduction of an Exogenous miRNA
por: Nagata, Yoshiro, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_petss2a9vlln414f1i2dgi11d7