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Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect

Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR). Luciferase reporter assays and in silico docking studies s...

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Detalles Bibliográficos
Autores principales:	Tamura, Satoru, Okada, Maiko, Kato, Shigeaki, Shinoda, Yasuharu, Shioda, Norifumi, Fukunaga, Kohji, Ui-Tei, Kumiko, Ueda, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797171/ https://www.ncbi.nlm.nih.gov/pubmed/29396543 http://dx.doi.org/10.1038/s41598-018-20663-z

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