Blocking extracellular activation of myostatin as a strategy for treating muscle wasting

Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic cleavages to release the growth factor from the pr...

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Detalles Bibliográficos
Autores principales: Pirruccello-Straub, M., Jackson, J., Wawersik, S., Webster, M. T., Salta, L., Long, K., McConaughy, W., Capili, A., Boston, C., Carven, G. J., Mahanthappa, N. K., Turner, K. J., Donovan, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797207/
https://www.ncbi.nlm.nih.gov/pubmed/29396542
http://dx.doi.org/10.1038/s41598-018-20524-9

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