TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole

Amyotrophic lateral sclerosis (ALS) represents a fatal neurodegenerative disease, which is characterized by a rapid loss of lower and upper motor neurons. As a major neuropathological hallmark, protein aggregates containing the Transactivating Response Region (TAR) DNA Binding Protein (TDP-43) are d...

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Detalles Bibliográficos
Autores principales: Oberstadt, Moritz, Stieler, Jens, Simpong, David Larbi, Römuß, Ute, Urban, Nicole, Schaefer, Michael, Arendt, Thomas, Holzer, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797228/
https://www.ncbi.nlm.nih.gov/pubmed/29396541
http://dx.doi.org/10.1038/s41598-018-20565-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797228/
https://www.ncbi.nlm.nih.gov/pubmed/29396541
http://dx.doi.org/10.1038/s41598-018-20565-0

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