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The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis
The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 ath...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797248/ https://www.ncbi.nlm.nih.gov/pubmed/29396405 http://dx.doi.org/10.1038/s41598-018-20434-w |
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author | Li, Jing Feng, Congrui Li, Liang Yang, Shujun Chen, Yu Hui, Rutai Zhang, Mei Zhang, Weili |
author_facet | Li, Jing Feng, Congrui Li, Liang Yang, Shujun Chen, Yu Hui, Rutai Zhang, Mei Zhang, Weili |
author_sort | Li, Jing |
collection | PubMed |
description | The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 atherothrombotic stroke, 94 hemorrhagic stroke and 225 lacunar infraction) and 616 controls and replicated the investigation in an independent study comprising 773 cases and 875 controls with the same diagnostic criteria. Telomere was inversely correlated with increasing age in controls (correlation coefficient γ = −0.28, P < 0.001) and in cases with atherothrombotic stroke (γ = −0.17, P = 0.012). Individuals within the lowest tertile of telomere showed a higher risk for atherothrombotic stroke [odds ratio 2.33, 95% confidence (CI) 1.42–3.83; P = 0.003], whereas had a lower presence of lacunar infarction (OR 0.49, 95% CI 0.30–0.81; P = 0.007). Similar results were obtained in the second replication study. A further meta-analysis showed a 12% increased pooled risk of ischemic stroke (95% CI 1.04–1.18) in relation to shorter telomere, but this association was stronger in the retrospective studies and in Asians when stratified by study design and ethnicity. Our data provided the first evidence that in Southern Chinese stroke population, leukocyte telomere is independently associated with atherothrombotic stroke and lacunar infarction. |
format | Online Article Text |
id | pubmed-5797248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57972482018-02-13 The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis Li, Jing Feng, Congrui Li, Liang Yang, Shujun Chen, Yu Hui, Rutai Zhang, Mei Zhang, Weili Sci Rep Article The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 atherothrombotic stroke, 94 hemorrhagic stroke and 225 lacunar infraction) and 616 controls and replicated the investigation in an independent study comprising 773 cases and 875 controls with the same diagnostic criteria. Telomere was inversely correlated with increasing age in controls (correlation coefficient γ = −0.28, P < 0.001) and in cases with atherothrombotic stroke (γ = −0.17, P = 0.012). Individuals within the lowest tertile of telomere showed a higher risk for atherothrombotic stroke [odds ratio 2.33, 95% confidence (CI) 1.42–3.83; P = 0.003], whereas had a lower presence of lacunar infarction (OR 0.49, 95% CI 0.30–0.81; P = 0.007). Similar results were obtained in the second replication study. A further meta-analysis showed a 12% increased pooled risk of ischemic stroke (95% CI 1.04–1.18) in relation to shorter telomere, but this association was stronger in the retrospective studies and in Asians when stratified by study design and ethnicity. Our data provided the first evidence that in Southern Chinese stroke population, leukocyte telomere is independently associated with atherothrombotic stroke and lacunar infarction. Nature Publishing Group UK 2018-02-02 /pmc/articles/PMC5797248/ /pubmed/29396405 http://dx.doi.org/10.1038/s41598-018-20434-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Jing Feng, Congrui Li, Liang Yang, Shujun Chen, Yu Hui, Rutai Zhang, Mei Zhang, Weili The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title | The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title_full | The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title_fullStr | The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title_full_unstemmed | The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title_short | The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis |
title_sort | association of telomere attrition with first-onset stroke in southern chinese: a case-control study and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797248/ https://www.ncbi.nlm.nih.gov/pubmed/29396405 http://dx.doi.org/10.1038/s41598-018-20434-w |
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