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Duodenal amyloidosis secondary to ulcerative colitis
Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association for the Study of Intestinal Diseases
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797263/ https://www.ncbi.nlm.nih.gov/pubmed/29422811 http://dx.doi.org/10.5217/ir.2018.16.1.151 |
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author | Park, Seung Woon Jee, Sam Ryong Kim, Ji Hyun Lee, Sang Heon Hwang, Jin Won Jang, Ji Geon Lee, Dong Woo Seol, Sang Yong |
author_facet | Park, Seung Woon Jee, Sam Ryong Kim, Ji Hyun Lee, Sang Heon Hwang, Jin Won Jang, Ji Geon Lee, Dong Woo Seol, Sang Yong |
author_sort | Park, Seung Woon |
collection | PubMed |
description | Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy. |
format | Online Article Text |
id | pubmed-5797263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Association for the Study of Intestinal Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-57972632018-02-08 Duodenal amyloidosis secondary to ulcerative colitis Park, Seung Woon Jee, Sam Ryong Kim, Ji Hyun Lee, Sang Heon Hwang, Jin Won Jang, Ji Geon Lee, Dong Woo Seol, Sang Yong Intest Res Case Report Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy. Korean Association for the Study of Intestinal Diseases 2018-01 2018-01-18 /pmc/articles/PMC5797263/ /pubmed/29422811 http://dx.doi.org/10.5217/ir.2018.16.1.151 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Park, Seung Woon Jee, Sam Ryong Kim, Ji Hyun Lee, Sang Heon Hwang, Jin Won Jang, Ji Geon Lee, Dong Woo Seol, Sang Yong Duodenal amyloidosis secondary to ulcerative colitis |
title | Duodenal amyloidosis secondary to ulcerative colitis |
title_full | Duodenal amyloidosis secondary to ulcerative colitis |
title_fullStr | Duodenal amyloidosis secondary to ulcerative colitis |
title_full_unstemmed | Duodenal amyloidosis secondary to ulcerative colitis |
title_short | Duodenal amyloidosis secondary to ulcerative colitis |
title_sort | duodenal amyloidosis secondary to ulcerative colitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797263/ https://www.ncbi.nlm.nih.gov/pubmed/29422811 http://dx.doi.org/10.5217/ir.2018.16.1.151 |
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