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Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects

BACKGROUND: Inhalation exposure to fine and ultrafine particles (UFPs) has been associated with respiratory diseases. However, little is known on the quality, threshold levels and concentration of these particles causing adverse health effects. METHODS: The impact of occupational exposure to submicr...

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Autores principales: Jordakieva, G., Grabovac, I., Valic, E., Schmidt, K. E., Graff, A., Schuster, A., Hoffmann-Sommergruber, K., Oberhuber, C., Scheiner, O., Goll, A., Godnic-Cvar, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797339/
https://www.ncbi.nlm.nih.gov/pubmed/29434649
http://dx.doi.org/10.1186/s12995-018-0187-8
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author Jordakieva, G.
Grabovac, I.
Valic, E.
Schmidt, K. E.
Graff, A.
Schuster, A.
Hoffmann-Sommergruber, K.
Oberhuber, C.
Scheiner, O.
Goll, A.
Godnic-Cvar, J.
author_facet Jordakieva, G.
Grabovac, I.
Valic, E.
Schmidt, K. E.
Graff, A.
Schuster, A.
Hoffmann-Sommergruber, K.
Oberhuber, C.
Scheiner, O.
Goll, A.
Godnic-Cvar, J.
author_sort Jordakieva, G.
collection PubMed
description BACKGROUND: Inhalation exposure to fine and ultrafine particles (UFPs) has been associated with respiratory diseases. However, little is known on the quality, threshold levels and concentration of these particles causing adverse health effects. METHODS: The impact of occupational exposure to submicrometer and UFPs was assessed in 30 healthy police shooting instructors by clinical investigation, self-assessment questionnaire, sputum and spirometry and compared to a control group. General laboratory chemistry parameters, circulating cytokines (interleukin [IL]-2, IL-4, IL-5, IL-6, IL-8, interferon-gamma [IFN-γ]), and granulocyte macrophage colony-stimulating factor (GM-CSF) in serum were measured. UFP exposure was recorded by Scanning Mobility Particle Sizer. RESULTS: Concentrations of submicrometer sized airborne particles (< 700 nm) measured between 3.34 × 10(5)/cm(3) and 7.58 × 10(5)/cm(3) at shooting sites, with highest concentrations found in the UFP range (< 100 nm). The size of the monodispersed particles ranged from 54.74 ± 16.25 nm to 98.19 ± 22.83 nm. Short term exposure (4 h) to high levels of UFPs caused an increase of IFN-γ in exposed subjects (p = 0.022). 24 h after exposure a significant decrease of IgG, albumin fibrinogen and factor VII was found. Neither directly after 4 h of high levels UFPs exposure nor 24 h after exposure subjective complaints or objective measurements indicating adverse respiratory effects in exposed subjects were found. CONCLUSIONS: No consistent indications for adverse respiratory or inflammatory effects directly following exposure and 24 h after exposure to high levels of UFPs in our study group were detected. However we showed the assessment of short-term exposure effects at a genuine occupational setting, which might is relevant when a risk assessment of high level occupational exposures to UFPs is considered.
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spelling pubmed-57973392018-02-12 Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects Jordakieva, G. Grabovac, I. Valic, E. Schmidt, K. E. Graff, A. Schuster, A. Hoffmann-Sommergruber, K. Oberhuber, C. Scheiner, O. Goll, A. Godnic-Cvar, J. J Occup Med Toxicol Research BACKGROUND: Inhalation exposure to fine and ultrafine particles (UFPs) has been associated with respiratory diseases. However, little is known on the quality, threshold levels and concentration of these particles causing adverse health effects. METHODS: The impact of occupational exposure to submicrometer and UFPs was assessed in 30 healthy police shooting instructors by clinical investigation, self-assessment questionnaire, sputum and spirometry and compared to a control group. General laboratory chemistry parameters, circulating cytokines (interleukin [IL]-2, IL-4, IL-5, IL-6, IL-8, interferon-gamma [IFN-γ]), and granulocyte macrophage colony-stimulating factor (GM-CSF) in serum were measured. UFP exposure was recorded by Scanning Mobility Particle Sizer. RESULTS: Concentrations of submicrometer sized airborne particles (< 700 nm) measured between 3.34 × 10(5)/cm(3) and 7.58 × 10(5)/cm(3) at shooting sites, with highest concentrations found in the UFP range (< 100 nm). The size of the monodispersed particles ranged from 54.74 ± 16.25 nm to 98.19 ± 22.83 nm. Short term exposure (4 h) to high levels of UFPs caused an increase of IFN-γ in exposed subjects (p = 0.022). 24 h after exposure a significant decrease of IgG, albumin fibrinogen and factor VII was found. Neither directly after 4 h of high levels UFPs exposure nor 24 h after exposure subjective complaints or objective measurements indicating adverse respiratory effects in exposed subjects were found. CONCLUSIONS: No consistent indications for adverse respiratory or inflammatory effects directly following exposure and 24 h after exposure to high levels of UFPs in our study group were detected. However we showed the assessment of short-term exposure effects at a genuine occupational setting, which might is relevant when a risk assessment of high level occupational exposures to UFPs is considered. BioMed Central 2018-02-03 /pmc/articles/PMC5797339/ /pubmed/29434649 http://dx.doi.org/10.1186/s12995-018-0187-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Jordakieva, G.
Grabovac, I.
Valic, E.
Schmidt, K. E.
Graff, A.
Schuster, A.
Hoffmann-Sommergruber, K.
Oberhuber, C.
Scheiner, O.
Goll, A.
Godnic-Cvar, J.
Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title_full Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title_fullStr Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title_full_unstemmed Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title_short Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
title_sort occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797339/
https://www.ncbi.nlm.nih.gov/pubmed/29434649
http://dx.doi.org/10.1186/s12995-018-0187-8
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