An Essential Postdevelopmental Role for Lis1 in Mice

LIS1 mutations cause lissencephaly (LIS), a severe developmental brain malformation. Much less is known about its role in the mature nervous system. LIS1 regulates the microtubule motor cytoplasmic dynein 1 (dynein), and as LIS1 and dynein are both expressed in the adult nervous system, Lis1 could p...

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Detalles Bibliográficos
Autores principales: Hines, Timothy J., Gao, Xu, Sahu, Subhshri, Lange, Meghann M., Turner, Jill R., Twiss, Jeffery L., Smith, Deanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797476/
https://www.ncbi.nlm.nih.gov/pubmed/29404402
http://dx.doi.org/10.1523/ENEURO.0350-17.2018

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