The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis. Bcl-2 homology-3 domain (BH3)-only proteins are pro-apoptotic members of the Bcl-2 family whose enhanc...

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Detalles Bibliográficos
Autores principales: Duval, Nathan, Sumner, Whitney A., Andrianakos, Anna G., Gray, Josie J., Bouchard, Ron J., Wilkins, Heather M., Linseman, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797550/
https://www.ncbi.nlm.nih.gov/pubmed/29440992
http://dx.doi.org/10.3389/fncel.2018.00015

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