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Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment
Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient’s quality of life, particularly in the chronic-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797560/ https://www.ncbi.nlm.nih.gov/pubmed/28656563 http://dx.doi.org/10.1007/s40257-017-0306-9 |
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author | Strong Rodrigues, Karla Oliveira-Ribeiro, Carla de Abreu Fiuza Gomes, Silvia Knobler, Robert |
author_facet | Strong Rodrigues, Karla Oliveira-Ribeiro, Carla de Abreu Fiuza Gomes, Silvia Knobler, Robert |
author_sort | Strong Rodrigues, Karla |
collection | PubMed |
description | Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient’s quality of life, particularly in the chronic-stage setting. Many different organs can be involved, which leads to a wide range of clinical manifestations. In this context, dermatologists play a key role by diagnosing and treating GVHD from the outset since cutaneous features are not just the most common but are also usually the presenting sign. Several skin-direct therapies are available and may be indicated as monotherapy or adjuvant treatment in order to allow faster tapering and withdrawal of systemic immunosuppression. Treatment of steroid-refractory patients remains a challenge and, to date, no consensus has been reached for one single agent in second-line therapy. This article aims to review skin involvement as well as provide and update discussion on therapeutic options for both acute and chronic cutaneous GVHD. |
format | Online Article Text |
id | pubmed-5797560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57975602018-02-09 Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment Strong Rodrigues, Karla Oliveira-Ribeiro, Carla de Abreu Fiuza Gomes, Silvia Knobler, Robert Am J Clin Dermatol Review Article Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient’s quality of life, particularly in the chronic-stage setting. Many different organs can be involved, which leads to a wide range of clinical manifestations. In this context, dermatologists play a key role by diagnosing and treating GVHD from the outset since cutaneous features are not just the most common but are also usually the presenting sign. Several skin-direct therapies are available and may be indicated as monotherapy or adjuvant treatment in order to allow faster tapering and withdrawal of systemic immunosuppression. Treatment of steroid-refractory patients remains a challenge and, to date, no consensus has been reached for one single agent in second-line therapy. This article aims to review skin involvement as well as provide and update discussion on therapeutic options for both acute and chronic cutaneous GVHD. Springer International Publishing 2017-06-27 2018 /pmc/articles/PMC5797560/ /pubmed/28656563 http://dx.doi.org/10.1007/s40257-017-0306-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Article Strong Rodrigues, Karla Oliveira-Ribeiro, Carla de Abreu Fiuza Gomes, Silvia Knobler, Robert Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title | Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title_full | Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title_fullStr | Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title_full_unstemmed | Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title_short | Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment |
title_sort | cutaneous graft-versus-host disease: diagnosis and treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797560/ https://www.ncbi.nlm.nih.gov/pubmed/28656563 http://dx.doi.org/10.1007/s40257-017-0306-9 |
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