Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death. Abnormalities at the neuromuscular junction (NMJ) have been reported in SMA, including neurofi...

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Detalles Bibliográficos
Autores principales: Boido, Marina, De Amicis, Elena, Valsecchi, Valeria, Trevisan, Marco, Ala, Ugo, Ruegg, Markus A., Hettwer, Stefan, Vercelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797594/
https://www.ncbi.nlm.nih.gov/pubmed/29440993
http://dx.doi.org/10.3389/fncel.2018.00017

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