Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or tran...

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Autores principales: Hippen, Keli L., Loschi, Michael, Nicholls, Jemma, MacDonald, Kelli P. A., Blazar, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797736/
https://www.ncbi.nlm.nih.gov/pubmed/29445371
http://dx.doi.org/10.3389/fimmu.2018.00057
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author Hippen, Keli L.
Loschi, Michael
Nicholls, Jemma
MacDonald, Kelli P. A.
Blazar, Bruce R.
author_facet Hippen, Keli L.
Loschi, Michael
Nicholls, Jemma
MacDonald, Kelli P. A.
Blazar, Bruce R.
author_sort Hippen, Keli L.
collection PubMed
description Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.
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spelling pubmed-57977362018-02-14 Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease Hippen, Keli L. Loschi, Michael Nicholls, Jemma MacDonald, Kelli P. A. Blazar, Bruce R. Front Immunol Immunology Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice. Frontiers Media S.A. 2018-01-31 /pmc/articles/PMC5797736/ /pubmed/29445371 http://dx.doi.org/10.3389/fimmu.2018.00057 Text en Copyright © 2018 Hippen, Loschi, Nicholls, MacDonald and Blazar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hippen, Keli L.
Loschi, Michael
Nicholls, Jemma
MacDonald, Kelli P. A.
Blazar, Bruce R.
Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_full Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_fullStr Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_full_unstemmed Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_short Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
title_sort effects of microrna on regulatory t cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797736/
https://www.ncbi.nlm.nih.gov/pubmed/29445371
http://dx.doi.org/10.3389/fimmu.2018.00057
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