The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors...

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Autores principales: Hornyák, Lilla, Dobos, Nikoletta, Koncz, Gábor, Karányi, Zsolt, Páll, Dénes, Szabó, Zoltán, Halmos, Gábor, Székvölgyi, Lóránt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797779/
https://www.ncbi.nlm.nih.gov/pubmed/29445380
http://dx.doi.org/10.3389/fimmu.2018.00151
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author Hornyák, Lilla
Dobos, Nikoletta
Koncz, Gábor
Karányi, Zsolt
Páll, Dénes
Szabó, Zoltán
Halmos, Gábor
Székvölgyi, Lóránt
author_facet Hornyák, Lilla
Dobos, Nikoletta
Koncz, Gábor
Karányi, Zsolt
Páll, Dénes
Szabó, Zoltán
Halmos, Gábor
Székvölgyi, Lóránt
author_sort Hornyák, Lilla
collection PubMed
description Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. Herein, we assess the biochemical role of IDO1 in tumor metabolism and immune surveillance, and review current diagnostic and therapeutic approaches that are intended to increase the effectiveness of immunotherapies against highly aggressive and difficult-to-treat IDO-expressing cancers.
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spelling pubmed-57977792018-02-14 The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy Hornyák, Lilla Dobos, Nikoletta Koncz, Gábor Karányi, Zsolt Páll, Dénes Szabó, Zoltán Halmos, Gábor Székvölgyi, Lóránt Front Immunol Immunology Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. Herein, we assess the biochemical role of IDO1 in tumor metabolism and immune surveillance, and review current diagnostic and therapeutic approaches that are intended to increase the effectiveness of immunotherapies against highly aggressive and difficult-to-treat IDO-expressing cancers. Frontiers Media S.A. 2018-01-31 /pmc/articles/PMC5797779/ /pubmed/29445380 http://dx.doi.org/10.3389/fimmu.2018.00151 Text en Copyright © 2018 Hornyák, Dobos, Koncz, Karányi, Páll, Szabó, Halmos and Székvölgyi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hornyák, Lilla
Dobos, Nikoletta
Koncz, Gábor
Karányi, Zsolt
Páll, Dénes
Szabó, Zoltán
Halmos, Gábor
Székvölgyi, Lóránt
The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title_full The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title_fullStr The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title_full_unstemmed The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title_short The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
title_sort role of indoleamine-2,3-dioxygenase in cancer development, diagnostics, and therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797779/
https://www.ncbi.nlm.nih.gov/pubmed/29445380
http://dx.doi.org/10.3389/fimmu.2018.00151
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