Cargando…

Ex Vivo Expanded Human Non-Cytotoxic CD8(+)CD45RC(low/−) Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice

Both CD4(+) and CD8(+) Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8(+) Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8(+)CD45RC(low/−)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bézie, Séverine, Meistermann, Dimitri, Boucault, Laetitia, Kilens, Stéphanie, Zoppi, Johanna, Autrusseau, Elodie, Donnart, Audrey, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Charpentier, Eric, Duteille, Franck, David, Laurent, Anegon, Ignacio, Guillonneau, Carole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797797/ https://www.ncbi.nlm.nih.gov/pubmed/29445370 http://dx.doi.org/10.3389/fimmu.2017.02014

Ejemplares similares

Genetic engineering of human and mouse CD4(+) and CD8(+) Tregs using lentiviral vectors encoding chimeric antigen receptors
por: Vimond, Nadège, et al.
Publicado: (2020)

IL-34 Actions on FOXP3(+) Tregs and CD14(+) Monocytes Control Human Graft Rejection
por: Bézie, Séverine, et al.
Publicado: (2020)

Future prospects for CD8(+) regulatory T cells in immune tolerance
por: Flippe, Léa, et al.
Publicado: (2019)

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications
por: Amini, Leila, et al.
Publicado: (2021)

Alloantigenic recognition properties of CD8(+) regulatory T cells
por: Picarda, Elodie, et al.
Publicado: (2011)

Generation of CD34(+)CD43(+) Hematopoietic Progenitors to Induce Thymocytes from Human Pluripotent Stem Cells
por: Flippe, Léa, et al.
Publicado: (2022)

IL‐34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis
por: Freuchet, Antoine, et al.
Publicado: (2022)

Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy syndrome
por: Besnard, Marine, et al.
Publicado: (2022)

Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment
por: Ouisse, Laure-Hélène, et al.
Publicado: (2019)

Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8(+) Regulatory T Cells
por: Benallegue, Nail, et al.
Publicado: (2022)

Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality
por: Holtan, Shernan G., et al.
Publicado: (2023)

Tranilast, an analogue of tryptophan catabolites, induces allograft tolerance by CD161(+) cells
por: Ménoret, Séverine, et al.
Publicado: (2011)

SIRPγ-CD47 Interaction Positively Regulates the Activation of Human T Cells in Situation of Chronic Stimulation
por: Dehmani, Safa, et al.
Publicado: (2021)

Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells
por: Gao, Ya, et al.
Publicado: (2021)

Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy
por: Brown, Matthew E., et al.
Publicado: (2022)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology
por: Hess, Nicholas J., et al.
Publicado: (2023)

Circulating CD4(+) Treg, CD8(+) Treg, and CD3(+) γδ T Cell Subpopulations in Ovarian Cancer
por: Li, Rong, et al.
Publicado: (2023)

Exosomes, MDSCs and Tregs: A new frontier for GVHD prevention and treatment
por: Hess, Nicholas J., et al.
Publicado: (2023)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
por: Landwehr-Kenzel, Sybille, et al.
Publicado: (2021)

Hepatitis B envelope antigen increases Tregs by converting CD4+CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) Tregs
por: Tang, Rui, et al.
Publicado: (2020)

Immunosuppressive role of fibrinogen-like protein 2 (FGL2) in CD8(+)regulatory T cells-mediated long-term graft survival
por: Bézie, Séverine, et al.
Publicado: (2011)

Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4(+) and CD8(+) Tregs That Are Functional in Humanized Mice
por: Giang, Sophia, et al.
Publicado: (2021)

CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
por: Nowak, Anna, et al.
Publicado: (2018)

Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Roberto, Crocchiolo, et al.
Publicado: (2021)

Evidence for CD19B–CD8T cell interactions in blood and tissues from patients with GvHD
por: Deola, S, et al.
Publicado: (2017)

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells
por: Kilens, Stéphanie, et al.
Publicado: (2018)

Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice
por: Abraham, Sojan, et al.
Publicado: (2017)

Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection
por: Thorborn, Georgina, et al.
Publicado: (2010)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Crocchiolo, Roberto, et al.
Publicado: (2021)

A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells
por: Ordonez, Laurence, et al.
Publicado: (2013)

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways
por: Ni, Xuhao, et al.
Publicado: (2019)

Human and Mouse CD8(+)CD25(+)FOXP3(+) Regulatory T Cells at Steady State and during Interleukin-2 Therapy
por: Churlaud, Guillaume, et al.
Publicado: (2015)

Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model
por: Lee, Eun-Sol, et al.
Publicado: (2015)

CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis
por: Soskic, Blagoje, et al.
Publicado: (2021)

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation
por: Peters, Jorieke H., et al.
Publicado: (2008)

Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD
por: Flinn, Aisling M., et al.
Publicado: (2021)

Regulation of extrathymic Treg cell conversion by CD5
por: Henderson, Jacob G., et al.
Publicado: (2015)

CD4(+) and CD8(+) regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model
por: Ménoret, Séverine, et al.
Publicado: (2023)

Early myeloid-derived suppressor cells (HLA-DR(−)/(low)CD33(+)CD16(−)) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT
por: Wang, Ke, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gppdf70jqqjnk5dnqlh3h554eh