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PRIMA‐1 induces p53‐mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation

TP53 is associated with the resistance of cytotoxic treatment and patient prognosis, and the mutation rate of TP53 in esophageal squamous cell carcinoma (ESCC) is extraordinarily high, at over 90%. PRIMA‐1 (p53 re‐activation and induction of massive apoptosis) has recently been reported to restore t...

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Detalles Bibliográficos
Autores principales:	Furukawa, Haruna, Makino, Tomoki, Yamasaki, Makoto, Tanaka, Koji, Miyazaki, Yasuhiro, Takahashi, Tsuyoshi, Kurokawa, Yukinori, Nakajima, Kiyokazu, Takiguchi, Shuji, Mori, Masaki, Doki, Yuichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797815/ https://www.ncbi.nlm.nih.gov/pubmed/29168598 http://dx.doi.org/10.1111/cas.13454

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