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Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan)
Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 week...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797856/ https://www.ncbi.nlm.nih.gov/pubmed/29118312 http://dx.doi.org/10.1292/jvms.17-0315 |
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author | JARUJAREET, Wipaporn TAIRA, Kensuke OOI, Hong Kean |
author_facet | JARUJAREET, Wipaporn TAIRA, Kensuke OOI, Hong Kean |
author_sort | JARUJAREET, Wipaporn |
collection | PubMed |
description | Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct. However, no significant increase in serum gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were observed. This could reflect reduced or minimal injury of bile ducts and biliary epithelia as the flukes had reached the adult stage. Alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) were not detected in the infected rabbit during the course of the experiment. Serum liver enzymes monitoring might be useful for understanding the host-parasite relationship in fascioliasis. |
format | Online Article Text |
id | pubmed-5797856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57978562018-02-08 Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) JARUJAREET, Wipaporn TAIRA, Kensuke OOI, Hong Kean J Vet Med Sci Parasitology Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct. However, no significant increase in serum gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were observed. This could reflect reduced or minimal injury of bile ducts and biliary epithelia as the flukes had reached the adult stage. Alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) were not detected in the infected rabbit during the course of the experiment. Serum liver enzymes monitoring might be useful for understanding the host-parasite relationship in fascioliasis. The Japanese Society of Veterinary Science 2017-11-09 2018-01 /pmc/articles/PMC5797856/ /pubmed/29118312 http://dx.doi.org/10.1292/jvms.17-0315 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Parasitology JARUJAREET, Wipaporn TAIRA, Kensuke OOI, Hong Kean Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title | Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title_full | Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title_fullStr | Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title_full_unstemmed | Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title_short | Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan) |
title_sort | dynamics of liver enzymes in rabbits experimentally infected with fasciola sp. (intermediate form from japan) |
topic | Parasitology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797856/ https://www.ncbi.nlm.nih.gov/pubmed/29118312 http://dx.doi.org/10.1292/jvms.17-0315 |
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