Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors

Hepatitis C virus (HCV) readily establishes chronic infection, which is characterized by failure of virus-specific CD8(+) T cells. HCV uses epitope mutation and T-cell exhaustion to escape from the host immune response. Previously, we engineered high-affinity T-cell receptors (HATs) targeting human...

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Detalles Bibliográficos
Autores principales: Zhang, Huajun, Zhang, Jianbing, Chen, Lei, Weng, Zhiming, Tian, Ye, Zhao, Haifeng, Li, Youjia, Chen, Lin, Liang, Zhaoduan, Zheng, Hongjun, Zhao, Wenzhuo, Zhong, Shi, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797947/
https://www.ncbi.nlm.nih.gov/pubmed/27902325
http://dx.doi.org/10.1099/jgv.0.000656

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