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Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells

The foot-and-mouth disease virus (FMDV) capsid precursor, P1-2A, is cleaved by FMDV 3C protease to yield VP0, VP3, VP1 and 2A. Cleavage of the VP1/2A junction is the slowest. Serotype O FMDVs with uncleaved VP1-2A (having a K210E substitution in VP1; at position P2 in cleavage site) have been descri...

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Detalles Bibliográficos
Autores principales:	Kristensen, Thea, Normann, Preben, Gullberg, Maria, Fahnøe, Ulrik, Polacek, Charlotta, Rasmussen, Thomas Bruun, Belsham, Graham J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797948/ https://www.ncbi.nlm.nih.gov/pubmed/27902359 http://dx.doi.org/10.1099/jgv.0.000664

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