Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy

We report a case of rituximab-induced serum sickness in a 50-year-old female with idiopathic membranous nephropathy. Presentation was characterized by a widespread rash 1 week after rituximab administration followed by fever and profound haemodynamic instability, mimicking sepsis. Symptoms resolved...

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Detalles Bibliográficos
Autores principales: Cheong, Jamie, Ooi, Khai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Glomerulonephritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798076/
https://www.ncbi.nlm.nih.gov/pubmed/29423201
http://dx.doi.org/10.1093/ckj/sfx072
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author Cheong, Jamie
Ooi, Khai
author_facet Cheong, Jamie
Ooi, Khai
author_sort Cheong, Jamie
collection PubMed
description We report a case of rituximab-induced serum sickness in a 50-year-old female with idiopathic membranous nephropathy. Presentation was characterized by a widespread rash 1 week after rituximab administration followed by fever and profound haemodynamic instability, mimicking sepsis. Symptoms resolved over 48 h, although adjunct antibiotics, steroids and inotropes were used. This case is notable for being the first reaction with rituximab for a renal indication as well as the severity of presentation.
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spelling pubmed-57980762018-02-08 Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy Cheong, Jamie Ooi, Khai Clin Kidney J Glomerulonephritis We report a case of rituximab-induced serum sickness in a 50-year-old female with idiopathic membranous nephropathy. Presentation was characterized by a widespread rash 1 week after rituximab administration followed by fever and profound haemodynamic instability, mimicking sepsis. Symptoms resolved over 48 h, although adjunct antibiotics, steroids and inotropes were used. This case is notable for being the first reaction with rituximab for a renal indication as well as the severity of presentation. Oxford University Press 2018-02 2017-08-10 /pmc/articles/PMC5798076/ /pubmed/29423201 http://dx.doi.org/10.1093/ckj/sfx072 Text en © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Glomerulonephritis
Cheong, Jamie
Ooi, Khai
Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title_full Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title_fullStr Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title_full_unstemmed Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title_short Rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
title_sort rituximab-induced serum sickness in the treatment of idiopathic membranous nephropathy
topic Glomerulonephritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798076/
https://www.ncbi.nlm.nih.gov/pubmed/29423201
http://dx.doi.org/10.1093/ckj/sfx072
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