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Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau
BACKGROUND: Gray matter changes associated with the progression of Alzheimer’s disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention, particularly during early or preclinical stages of the disease. OBJECTIVE: To identify the structural co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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IOS Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798529/ https://www.ncbi.nlm.nih.gov/pubmed/29376852 http://dx.doi.org/10.3233/JAD-170553 |
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author | Tucholka, Alan Grau-Rivera, Oriol Falcon, Carles Rami, Lorena Sánchez-Valle, Raquel Lladó, Albert Gispert, Juan Domingo Molinuevo, José Luis |
author_facet | Tucholka, Alan Grau-Rivera, Oriol Falcon, Carles Rami, Lorena Sánchez-Valle, Raquel Lladó, Albert Gispert, Juan Domingo Molinuevo, José Luis |
author_sort | Tucholka, Alan |
collection | PubMed |
description | BACKGROUND: Gray matter changes associated with the progression of Alzheimer’s disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention, particularly during early or preclinical stages of the disease. OBJECTIVE: To identify the structural connectivity changes across the AD continuum. METHODS: We performed probabilistic tractography in a total of 183 subjects on two independent samples that include control (n = 68) and preclinical AD individuals (n = 28), patients diagnosed with mild cognitive impairment (MCI) due to AD (n = 44), and AD patients (n = 43). We compared the connectivity between groups, and with CSF Aβ(42) and tau biomarkers. RESULTS: We observed disconnections in preclinical individuals, mainly located in the temporal lobe. This pattern of disconnection spread to the parietal and frontal lobes at the MCI stage and involved almost all the brain in AD. These findings were not driven by gray matter atrophy. DISCUSSION: Using tractography, we were able to identify white matter changes between subsequent disease stages and, notably, also in preclinical AD. Therefore, this method may be useful for detecting early and specific brain structural changes during preclinical AD stage. |
format | Online Article Text |
id | pubmed-5798529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57985292018-02-08 Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau Tucholka, Alan Grau-Rivera, Oriol Falcon, Carles Rami, Lorena Sánchez-Valle, Raquel Lladó, Albert Gispert, Juan Domingo Molinuevo, José Luis J Alzheimers Dis Research Article BACKGROUND: Gray matter changes associated with the progression of Alzheimer’s disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention, particularly during early or preclinical stages of the disease. OBJECTIVE: To identify the structural connectivity changes across the AD continuum. METHODS: We performed probabilistic tractography in a total of 183 subjects on two independent samples that include control (n = 68) and preclinical AD individuals (n = 28), patients diagnosed with mild cognitive impairment (MCI) due to AD (n = 44), and AD patients (n = 43). We compared the connectivity between groups, and with CSF Aβ(42) and tau biomarkers. RESULTS: We observed disconnections in preclinical individuals, mainly located in the temporal lobe. This pattern of disconnection spread to the parietal and frontal lobes at the MCI stage and involved almost all the brain in AD. These findings were not driven by gray matter atrophy. DISCUSSION: Using tractography, we were able to identify white matter changes between subsequent disease stages and, notably, also in preclinical AD. Therefore, this method may be useful for detecting early and specific brain structural changes during preclinical AD stage. IOS Press 2018-01-23 /pmc/articles/PMC5798529/ /pubmed/29376852 http://dx.doi.org/10.3233/JAD-170553 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tucholka, Alan Grau-Rivera, Oriol Falcon, Carles Rami, Lorena Sánchez-Valle, Raquel Lladó, Albert Gispert, Juan Domingo Molinuevo, José Luis Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title | Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title_full | Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title_fullStr | Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title_full_unstemmed | Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title_short | Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau |
title_sort | structural connectivity alterations along the alzheimer’s disease continuum: reproducibility across two independent samples and correlation with cerebrospinal fluid amyloid-β and tau |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798529/ https://www.ncbi.nlm.nih.gov/pubmed/29376852 http://dx.doi.org/10.3233/JAD-170553 |
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