Cargando…

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

BACKGROUND: Safe and effective delivery of therapeutic drugs to the brain is important for successful therapy of Alzheimer’s disease (AD). PURPOSE: To develop Huperzine A (HupA)-loaded, mucoadhesive and targeted polylactide-co-glycoside (PLGA) nanoparticles (NPs) with surface modification by lactofe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Qingqing, Wang, Aiping, Hua, Hongchen, Jiang, Ying, Wang, Yiyun, Mu, Hongjie, Wu, Zimei, Sun, Kaoxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798568/ https://www.ncbi.nlm.nih.gov/pubmed/29440896 http://dx.doi.org/10.2147/IJN.S151474

Ejemplares similares

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment
por: Bi, Chenchen, et al.
Publicado: (2016)

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
por: Tang, Shengnan, et al.
Publicado: (2019)

Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo
por: Duan, Dongyu, et al.
Publicado: (2018)

Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting
por: Chu, Liuxiang, et al.
Publicado: (2018)

Temozolomide hexadecyl ester targeted plga nanoparticles for drug-resistant glioblastoma therapy via intranasal administration
por: Wang, Siqi, et al.
Publicado: (2022)

Lactoferrin-modified rotigotine nanoparticles for enhanced nose-to-brain delivery: LESA-MS/MS-based drug biodistribution, pharmacodynamics, and neuroprotective effects
por: Yan, Xiuju, et al.
Publicado: (2018)

Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson’s disease
por: Jiang, Ying, et al.
Publicado: (2017)

Multivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization
por: Mu, Hongjie, et al.
Publicado: (2018)

Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease
por: Yan, Qinying, et al.
Publicado: (2020)

Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?
por: Qian, Zhong Ming, et al.
Publicado: (2014)

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
por: Friedli, María Jesús, et al.
Publicado: (2021)

Topical ocular delivery to laser-induced choroidal neovascularization by dual internalizing RGD and TAT peptide-modified nanoparticles
por: Chu, Yongchao, et al.
Publicado: (2017)

Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue
por: Zhang, Xuemei, et al.
Publicado: (2017)

Mucoadhesive PLGA Nanospheres and Nanocapsules for Lactoferrin Controlled Ocular Delivery
por: Varela-Fernández, Rubén, et al.
Publicado: (2022)

Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis
por: Xing, Shu-huai, et al.
Publicado: (2014)

Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent
por: Khanal, Pukar, et al.
Publicado: (2021)

Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
por: Kashyap, Sapna, et al.
Publicado: (2019)

The pharmacology and therapeutic potential of (−)-huperzine A
por: Tun, Maung Kyaw Moe, et al.
Publicado: (2012)

Examining the Interactome of Huperzine A by Magnetic Biopanning
por: Guo, Wei, et al.
Publicado: (2012)

Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
por: Yang, Guoyan, et al.
Publicado: (2013)

Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart
por: Szypuła, Wojciech J., et al.
Publicado: (2020)

Hypothesis: apo‐lactoferrin–Galantamine Proteo‐alkaloid Conjugate for Alzheimer's disease Intervention
por: Akilo, Olufemi D., et al.
Publicado: (2018)

Development and Optimization of Chitosan Nanoparticle-Based Intranasal Vaccine Carrier
por: Gao, Xiaoyi, et al.
Publicado: (2021)

Lactoferrin-Conjugated Nanoparticles as New Antivirals
por: Krzyzowska, Malgorzata, et al.
Publicado: (2022)

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy
por: Nanaki, Stavroula G., et al.
Publicado: (2020)

Disease-Modifying Activity of Huperzine A on Alzheimer’s Disease: Evidence from Preclinical Studies on Rodent Models
por: Yan, Ye-Piao, et al.
Publicado: (2022)

Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson’s disease and its evolution study
por: Wang, Aiping, et al.
Publicado: (2016)

Cross-presentation of lactoferrin encapsulated into chitosan-based nanoparticles
por: Lyalina, Tatiana, et al.
Publicado: (2016)

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
por: Malik, Anshu, et al.
Publicado: (2018)

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats
por: Mao, Xiao-Yuan, et al.
Publicado: (2014)

(68)Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation
por: Hajiramezanali, Maliheh, et al.
Publicado: (2019)

Trimethyl Chitosan Hydrogel Nanoparticles for Progesterone Delivery in Neurodegenerative Disorders †
por: Cardia, Maria Cristina, et al.
Publicado: (2019)

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease
por: Fan, Shengnuo, et al.
Publicado: (2018)

Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease
por: Mathew, Anila, et al.
Publicado: (2012)

Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment
por: Aghaei Delche, Nasim, et al.
Publicado: (2023)

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection
por: Yang, Xin, et al.
Publicado: (2020)

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens
por: Zhao, Kai, et al.
Publicado: (2021)

Chitosan, Chitosan/IgG-Loaded, and N-Trimethyl Chitosan Chloride Nanoparticles as Potential Adjuvant and Carrier-Delivery Systems
por: Tenorio-Barajas, Aldo Y., et al.
Publicado: (2023)

Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake
por: Li, Fang, et al.
Publicado: (2017)

Huperzine—A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation
por: Zhang, Hongyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ugbvovc1krkkrut9houebpu1ch