Early diagnostic potential of APC hypermethylation in esophageal cancer

BACKGROUND: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood. PURPOSE AND METHODS: The current study systematically reviewed studies on abn...

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Autores principales: Wang, Bujiang, Song, Haojun, Jiang, Haizhong, Fu, Yangbo, Ding, Xiaoyun, Zhou, Chongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798573/
https://www.ncbi.nlm.nih.gov/pubmed/29440928
http://dx.doi.org/10.2147/CMAR.S148677
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author Wang, Bujiang
Song, Haojun
Jiang, Haizhong
Fu, Yangbo
Ding, Xiaoyun
Zhou, Chongchang
author_facet Wang, Bujiang
Song, Haojun
Jiang, Haizhong
Fu, Yangbo
Ding, Xiaoyun
Zhou, Chongchang
author_sort Wang, Bujiang
collection PubMed
description BACKGROUND: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood. PURPOSE AND METHODS: The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett’s esophagus (BE), and 782 controls. RESULTS: Our results showed higher methylation of APC in EC (OR = 23.33, P < 0.001) and BE (OR = 9.34, P < 0.001) than in normal controls. Whereas APC methylation in EC was similar to that in BE (P = 0.052), it was not associated with tumor stage (P = 0.204). Additionally, APC methylation was not significantly associated with overall survival (OS) and relapse-free survival (RFS) in patients with EC. The performance of APC methylation for the detection of EC and BE achieved areas under the receiver operating characteristic curves of 0.94 and 0.88, respectively. CONCLUSION: Our results imply that APC methylation detection is a potential diagnostic biomarker for EC and BE.
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spelling pubmed-57985732018-02-13 Early diagnostic potential of APC hypermethylation in esophageal cancer Wang, Bujiang Song, Haojun Jiang, Haizhong Fu, Yangbo Ding, Xiaoyun Zhou, Chongchang Cancer Manag Res Original Research BACKGROUND: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood. PURPOSE AND METHODS: The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett’s esophagus (BE), and 782 controls. RESULTS: Our results showed higher methylation of APC in EC (OR = 23.33, P < 0.001) and BE (OR = 9.34, P < 0.001) than in normal controls. Whereas APC methylation in EC was similar to that in BE (P = 0.052), it was not associated with tumor stage (P = 0.204). Additionally, APC methylation was not significantly associated with overall survival (OS) and relapse-free survival (RFS) in patients with EC. The performance of APC methylation for the detection of EC and BE achieved areas under the receiver operating characteristic curves of 0.94 and 0.88, respectively. CONCLUSION: Our results imply that APC methylation detection is a potential diagnostic biomarker for EC and BE. Dove Medical Press 2018-02-01 /pmc/articles/PMC5798573/ /pubmed/29440928 http://dx.doi.org/10.2147/CMAR.S148677 Text en © 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wang, Bujiang
Song, Haojun
Jiang, Haizhong
Fu, Yangbo
Ding, Xiaoyun
Zhou, Chongchang
Early diagnostic potential of APC hypermethylation in esophageal cancer
title Early diagnostic potential of APC hypermethylation in esophageal cancer
title_full Early diagnostic potential of APC hypermethylation in esophageal cancer
title_fullStr Early diagnostic potential of APC hypermethylation in esophageal cancer
title_full_unstemmed Early diagnostic potential of APC hypermethylation in esophageal cancer
title_short Early diagnostic potential of APC hypermethylation in esophageal cancer
title_sort early diagnostic potential of apc hypermethylation in esophageal cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798573/
https://www.ncbi.nlm.nih.gov/pubmed/29440928
http://dx.doi.org/10.2147/CMAR.S148677
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