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Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inef...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798593/ https://www.ncbi.nlm.nih.gov/pubmed/29430568 http://dx.doi.org/10.1038/s41929-017-0001-5 |
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author | Zhang, Wuyuan Fernández-Fueyo, Elena Ni, Yan van Schie, Morten Gacs, Jenö Renirie, Rokus Wever, Ron Mutti, Francesco G. Rother, Dörte Alcalde, Miguel Hollmann, Frank |
author_facet | Zhang, Wuyuan Fernández-Fueyo, Elena Ni, Yan van Schie, Morten Gacs, Jenö Renirie, Rokus Wever, Ron Mutti, Francesco G. Rother, Dörte Alcalde, Miguel Hollmann, Frank |
author_sort | Zhang, Wuyuan |
collection | PubMed |
description | Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inefficient peroxide generation systems are required, which show little potential for large scale implementation. Here we show that visible light-driven, catalytic water oxidation can be used for in situ generation of H(2)O(2) from water, rendering the peroxygenase catalytically active. In this way the stereoselective oxyfunctionalisation of hydrocarbons can be achieved by simply using the catalytic system, water and visible light. |
format | Online Article Text |
id | pubmed-5798593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-57985932018-05-20 Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations Zhang, Wuyuan Fernández-Fueyo, Elena Ni, Yan van Schie, Morten Gacs, Jenö Renirie, Rokus Wever, Ron Mutti, Francesco G. Rother, Dörte Alcalde, Miguel Hollmann, Frank Nat Catal Article Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inefficient peroxide generation systems are required, which show little potential for large scale implementation. Here we show that visible light-driven, catalytic water oxidation can be used for in situ generation of H(2)O(2) from water, rendering the peroxygenase catalytically active. In this way the stereoselective oxyfunctionalisation of hydrocarbons can be achieved by simply using the catalytic system, water and visible light. 2017-11-20 2018-01 /pmc/articles/PMC5798593/ /pubmed/29430568 http://dx.doi.org/10.1038/s41929-017-0001-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Zhang, Wuyuan Fernández-Fueyo, Elena Ni, Yan van Schie, Morten Gacs, Jenö Renirie, Rokus Wever, Ron Mutti, Francesco G. Rother, Dörte Alcalde, Miguel Hollmann, Frank Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title | Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title_full | Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title_fullStr | Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title_full_unstemmed | Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title_short | Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
title_sort | selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798593/ https://www.ncbi.nlm.nih.gov/pubmed/29430568 http://dx.doi.org/10.1038/s41929-017-0001-5 |
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