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Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations

Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inef...

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Autores principales: Zhang, Wuyuan, Fernández-Fueyo, Elena, Ni, Yan, van Schie, Morten, Gacs, Jenö, Renirie, Rokus, Wever, Ron, Mutti, Francesco G., Rother, Dörte, Alcalde, Miguel, Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798593/
https://www.ncbi.nlm.nih.gov/pubmed/29430568
http://dx.doi.org/10.1038/s41929-017-0001-5
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author Zhang, Wuyuan
Fernández-Fueyo, Elena
Ni, Yan
van Schie, Morten
Gacs, Jenö
Renirie, Rokus
Wever, Ron
Mutti, Francesco G.
Rother, Dörte
Alcalde, Miguel
Hollmann, Frank
author_facet Zhang, Wuyuan
Fernández-Fueyo, Elena
Ni, Yan
van Schie, Morten
Gacs, Jenö
Renirie, Rokus
Wever, Ron
Mutti, Francesco G.
Rother, Dörte
Alcalde, Miguel
Hollmann, Frank
author_sort Zhang, Wuyuan
collection PubMed
description Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inefficient peroxide generation systems are required, which show little potential for large scale implementation. Here we show that visible light-driven, catalytic water oxidation can be used for in situ generation of H(2)O(2) from water, rendering the peroxygenase catalytically active. In this way the stereoselective oxyfunctionalisation of hydrocarbons can be achieved by simply using the catalytic system, water and visible light.
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spelling pubmed-57985932018-05-20 Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations Zhang, Wuyuan Fernández-Fueyo, Elena Ni, Yan van Schie, Morten Gacs, Jenö Renirie, Rokus Wever, Ron Mutti, Francesco G. Rother, Dörte Alcalde, Miguel Hollmann, Frank Nat Catal Article Peroxygenases offer attractive means to address challenges in selective oxyfunctionalisation chemistry. Despite their attractiveness, the application of peroxygenases in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant (H(2)O(2)). Often atom inefficient peroxide generation systems are required, which show little potential for large scale implementation. Here we show that visible light-driven, catalytic water oxidation can be used for in situ generation of H(2)O(2) from water, rendering the peroxygenase catalytically active. In this way the stereoselective oxyfunctionalisation of hydrocarbons can be achieved by simply using the catalytic system, water and visible light. 2017-11-20 2018-01 /pmc/articles/PMC5798593/ /pubmed/29430568 http://dx.doi.org/10.1038/s41929-017-0001-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhang, Wuyuan
Fernández-Fueyo, Elena
Ni, Yan
van Schie, Morten
Gacs, Jenö
Renirie, Rokus
Wever, Ron
Mutti, Francesco G.
Rother, Dörte
Alcalde, Miguel
Hollmann, Frank
Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title_full Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title_fullStr Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title_full_unstemmed Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title_short Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
title_sort selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798593/
https://www.ncbi.nlm.nih.gov/pubmed/29430568
http://dx.doi.org/10.1038/s41929-017-0001-5
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