Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder

ANK3, encoding the adaptor protein Ankyrin-G, has been implicated in bipolar disorder by genome wide association studies. ANK3 has multiple alternative first exons, and a bipolar disorder-associated ANK3 variant has been shown to reduce expression of exon 1b. Here we identify mechanisms through whic...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez, Angel Y., Wang, Xinjun, Xu, Mingxuan, Maheshwari, Atul, Curry, Daniel, Lam, Sandi, Adesina, Adekunle M., Noebels, Jeffrey L., Sun, Qian-Quan, Cooper, Edward C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798616/
https://www.ncbi.nlm.nih.gov/pubmed/27956739
http://dx.doi.org/10.1038/mp.2016.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798616/
https://www.ncbi.nlm.nih.gov/pubmed/27956739
http://dx.doi.org/10.1038/mp.2016.233

Ejemplares similares