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Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder
ANK3, encoding the adaptor protein Ankyrin-G, has been implicated in bipolar disorder by genome wide association studies. ANK3 has multiple alternative first exons, and a bipolar disorder-associated ANK3 variant has been shown to reduce expression of exon 1b. Here we identify mechanisms through whic...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798616/ https://www.ncbi.nlm.nih.gov/pubmed/27956739 http://dx.doi.org/10.1038/mp.2016.233 |