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Selective improvement of pulmonary arterial hypertension with a dual ET(A)/ET(B) receptors antagonist in the apolipoprotein E(−/−) model of PAH and atherosclerosis
Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co-morbid atherosclerosis. Apolipoprotein E-deficient (ApoE(−/−)) mice develop atherosclerosis with severe PAH when fed a high-fat diet (HFD) and have increased levels o...
Autores principales: | Renshall, Lewis, Arnold, Nadine, West, Laura, Braithwaite, Adam, Pickworth, Josephine, Walker, Rachel, Alfaidi, Mabruka, Chamberlain, Janet, Casbolt, Helen, Thompson, A.A. Roger, Holt, Cathy, Iglarz, Marc, Francis, Sheila, Lawrie, Allan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798688/ https://www.ncbi.nlm.nih.gov/pubmed/29261014 http://dx.doi.org/10.1177/2045893217752328 |
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