Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling

Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is a potent pericyte-stimulating factor in tumors. Mechanistically, FGF-2 binds to FGFR2 to s...

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Detalles Bibliográficos
Autores principales: Hosaka, Kayoko, Yang, Yunlong, Nakamura, Masaki, Andersson, Patrik, Yang, Xiaojuan, Zhang, Yin, Seki, Takahiro, Scherzer, Martin, Dubey, Olivier, Wang, Xinsheng, Cao, Yihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798893/
https://www.ncbi.nlm.nih.gov/pubmed/29423271
http://dx.doi.org/10.1038/s41421-017-0002-1

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