Cholesterol Crystal Embolism Induced by Direct Factor Xa Inhibitor: A First Case Report

An 80-year-old man presented at our hospital with renal failure. He had been treated with edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis for 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present in the bilateral...

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Detalles Bibliográficos
Autores principales: Oka, Hideaki, Kamimura, Taro, Hiramatsu, Yuki, Fukumitsu, Kento, Iwata, Rei, Kondo, Mika, Hirashima, Yutaro, Aihara, Seishi, Harada, Atsumi, Tsuruya, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799060/
https://www.ncbi.nlm.nih.gov/pubmed/28943551
http://dx.doi.org/10.2169/internalmedicine.8660-16
Descripción
Sumario:An 80-year-old man presented at our hospital with renal failure. He had been treated with edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis for 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present in the bilateral toes. Laboratory data indicated azotemia and eosinophilia. A skin biopsy confirmed a diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure was performed, we assumed that CCE was related to edoxaban. To the best of our knowledge, this is the first case report suggesting CCE induced by an Xa inhibitor.

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