Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis

Co-infection with cryptococcus and tuberculosis has rarely been reported. We herein report a case of an 80-year-old man with cryptococcal pleuritis concurrent with pulmonary tuberculosis. He was admitted for progression of left pleural effusion and consolidation in the left upper lobe. Culture for M...

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Autores principales: Kushima, Yoshitomo, Takizawa, Hidenori, Machida, Yasutaka, Umetsu, Takafumi, Ikeda, Naoya, Miyoshi, Masaaki, Chibana, Kazuyuki, Shimizu, Yasuo, Takemasa, Akihiro, Ishii, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799068/
https://www.ncbi.nlm.nih.gov/pubmed/29021481
http://dx.doi.org/10.2169/internalmedicine.9020-17
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author Kushima, Yoshitomo
Takizawa, Hidenori
Machida, Yasutaka
Umetsu, Takafumi
Ikeda, Naoya
Miyoshi, Masaaki
Chibana, Kazuyuki
Shimizu, Yasuo
Takemasa, Akihiro
Ishii, Yoshiki
author_facet Kushima, Yoshitomo
Takizawa, Hidenori
Machida, Yasutaka
Umetsu, Takafumi
Ikeda, Naoya
Miyoshi, Masaaki
Chibana, Kazuyuki
Shimizu, Yasuo
Takemasa, Akihiro
Ishii, Yoshiki
author_sort Kushima, Yoshitomo
collection PubMed
description Co-infection with cryptococcus and tuberculosis has rarely been reported. We herein report a case of an 80-year-old man with cryptococcal pleuritis concurrent with pulmonary tuberculosis. He was admitted for progression of left pleural effusion and consolidation in the left upper lobe. Culture for Mycobacterium tuberculosis was positive in sputum, and analyses of pleural effusion revealed lymphocyte-predominant high levels of adenosine deaminase (ADA). Medical thoracoscopy revealed massive infiltration of Cryptococcus neoformans in pleura without granuloma. This is the first case report of cryptococcal pleuritis coincident with pulmonary tuberculosis. Cryptococcal pleuritis should be ruled out when the adenosine deaminase levels are elevated in pleural effusion.
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spelling pubmed-57990682018-02-08 Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis Kushima, Yoshitomo Takizawa, Hidenori Machida, Yasutaka Umetsu, Takafumi Ikeda, Naoya Miyoshi, Masaaki Chibana, Kazuyuki Shimizu, Yasuo Takemasa, Akihiro Ishii, Yoshiki Intern Med Case Report Co-infection with cryptococcus and tuberculosis has rarely been reported. We herein report a case of an 80-year-old man with cryptococcal pleuritis concurrent with pulmonary tuberculosis. He was admitted for progression of left pleural effusion and consolidation in the left upper lobe. Culture for Mycobacterium tuberculosis was positive in sputum, and analyses of pleural effusion revealed lymphocyte-predominant high levels of adenosine deaminase (ADA). Medical thoracoscopy revealed massive infiltration of Cryptococcus neoformans in pleura without granuloma. This is the first case report of cryptococcal pleuritis coincident with pulmonary tuberculosis. Cryptococcal pleuritis should be ruled out when the adenosine deaminase levels are elevated in pleural effusion. The Japanese Society of Internal Medicine 2017-10-11 2018-01-01 /pmc/articles/PMC5799068/ /pubmed/29021481 http://dx.doi.org/10.2169/internalmedicine.9020-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kushima, Yoshitomo
Takizawa, Hidenori
Machida, Yasutaka
Umetsu, Takafumi
Ikeda, Naoya
Miyoshi, Masaaki
Chibana, Kazuyuki
Shimizu, Yasuo
Takemasa, Akihiro
Ishii, Yoshiki
Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title_full Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title_fullStr Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title_full_unstemmed Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title_short Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis
title_sort cryptococcal pleuritis presenting with lymphocyte-predominant and high levels of adenosine deaminase in pleural effusions coincident with pulmonary tuberculosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799068/
https://www.ncbi.nlm.nih.gov/pubmed/29021481
http://dx.doi.org/10.2169/internalmedicine.9020-17
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