Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria

Eculizumab is the complement inhibitor administered to ameliorate intravascular hemolysis in paroxysmal nocturnal hemoglobinuria. Whether or not the inhibitory mechanism may also increase the susceptibility to non-Neisserial infection is unclear. A 73-year old woman presented with bacteremia, cholec...

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Autores principales: Kawakami, Toru, Nakazawa, Hideyuki, Kurasawa, Yukifumi, Sakai, Hitoshi, Nishina, Sayaka, Senoo, Noriko, Senoo, Yasushi, Ishida, Fumihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799070/
https://www.ncbi.nlm.nih.gov/pubmed/29021487
http://dx.doi.org/10.2169/internalmedicine.9151-17
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author Kawakami, Toru
Nakazawa, Hideyuki
Kurasawa, Yukifumi
Sakai, Hitoshi
Nishina, Sayaka
Senoo, Noriko
Senoo, Yasushi
Ishida, Fumihiro
author_facet Kawakami, Toru
Nakazawa, Hideyuki
Kurasawa, Yukifumi
Sakai, Hitoshi
Nishina, Sayaka
Senoo, Noriko
Senoo, Yasushi
Ishida, Fumihiro
author_sort Kawakami, Toru
collection PubMed
description Eculizumab is the complement inhibitor administered to ameliorate intravascular hemolysis in paroxysmal nocturnal hemoglobinuria. Whether or not the inhibitory mechanism may also increase the susceptibility to non-Neisserial infection is unclear. A 73-year old woman presented with bacteremia, cholecystitis and liver abscess with Pseudomonas aeruginosa. Although she had been neutropenic for 21 years, she had no history of severe infection before eculizumab had been administered. The infection with P. aeruginosa was successfully controlled with antibiotics, granulocyte colony-stimulating factor and cholecystectomy. The present case might be representative of less common bacterial infections than Neisseria spp. among patients treated with eculizumab.
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spelling pubmed-57990702018-02-08 Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria Kawakami, Toru Nakazawa, Hideyuki Kurasawa, Yukifumi Sakai, Hitoshi Nishina, Sayaka Senoo, Noriko Senoo, Yasushi Ishida, Fumihiro Intern Med Case Report Eculizumab is the complement inhibitor administered to ameliorate intravascular hemolysis in paroxysmal nocturnal hemoglobinuria. Whether or not the inhibitory mechanism may also increase the susceptibility to non-Neisserial infection is unclear. A 73-year old woman presented with bacteremia, cholecystitis and liver abscess with Pseudomonas aeruginosa. Although she had been neutropenic for 21 years, she had no history of severe infection before eculizumab had been administered. The infection with P. aeruginosa was successfully controlled with antibiotics, granulocyte colony-stimulating factor and cholecystectomy. The present case might be representative of less common bacterial infections than Neisseria spp. among patients treated with eculizumab. The Japanese Society of Internal Medicine 2017-10-11 2018-01-01 /pmc/articles/PMC5799070/ /pubmed/29021487 http://dx.doi.org/10.2169/internalmedicine.9151-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawakami, Toru
Nakazawa, Hideyuki
Kurasawa, Yukifumi
Sakai, Hitoshi
Nishina, Sayaka
Senoo, Noriko
Senoo, Yasushi
Ishida, Fumihiro
Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title_full Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title_fullStr Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title_full_unstemmed Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title_short Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
title_sort severe infection of pseudomonas aeruginosa during eculizumab therapy for paroxysmal nocturnal hemoglobinuria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799070/
https://www.ncbi.nlm.nih.gov/pubmed/29021487
http://dx.doi.org/10.2169/internalmedicine.9151-17
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