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Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring

OBJECTIVES: Neurotoxicity of 1-bromopropane (1-BP) has been reported in occupational exposure, but whether the chemical exerts developmental neurotoxicity is unknown. We studied the effects of prenatal 1-BP exposure on neuronal excitability in rat offspring. METHODS: We exposed dams to 1-BP (700 ppm...

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Autores principales: Fueta, Yukiko, Ishidao, Toru, Ueno, Susumu, Yoshida, Yasuhiro, Kanda, Yasunari, Hori, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society for Occupational Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799103/
https://www.ncbi.nlm.nih.gov/pubmed/29093363
http://dx.doi.org/10.1539/joh.17-0009-BR
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author Fueta, Yukiko
Ishidao, Toru
Ueno, Susumu
Yoshida, Yasuhiro
Kanda, Yasunari
Hori, Hajime
author_facet Fueta, Yukiko
Ishidao, Toru
Ueno, Susumu
Yoshida, Yasuhiro
Kanda, Yasunari
Hori, Hajime
author_sort Fueta, Yukiko
collection PubMed
description OBJECTIVES: Neurotoxicity of 1-bromopropane (1-BP) has been reported in occupational exposure, but whether the chemical exerts developmental neurotoxicity is unknown. We studied the effects of prenatal 1-BP exposure on neuronal excitability in rat offspring. METHODS: We exposed dams to 1-BP (700 ppm, 6 h a day for 20 days) and examined hippocampal slices obtained from the male offspring at 2, 5, 8, and 13 weeks of age. We measured the stimulation/response (S/R) relationship and paired-pulse ratios (PPRs) of the population spike (PS) at the interpulse intervals (IPIs) of 5 and 10 ms in the CA1 subfield. RESULTS: Prenatal 1-BP exposure enhanced S/R relationships of PS at 2 weeks of age; however, the enhancement diminished at 5 weeks of age until it reached control levels. Prenatal 1-BP exposure decreased PPRs of PS at 2 weeks of age. After sexual maturation, however, the PPRs of PS increased at 5-ms IPI in rats aged 8 and 13 weeks. CONCLUSIONS: Our findings indicate that prenatal 1-BP exposure in dams can cause delayed adverse effects on excitability of pyramidal cells in the hippocampal CA1 subfield of offspring.
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spelling pubmed-57991032018-02-12 Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring Fueta, Yukiko Ishidao, Toru Ueno, Susumu Yoshida, Yasuhiro Kanda, Yasunari Hori, Hajime J Occup Health Brief Report OBJECTIVES: Neurotoxicity of 1-bromopropane (1-BP) has been reported in occupational exposure, but whether the chemical exerts developmental neurotoxicity is unknown. We studied the effects of prenatal 1-BP exposure on neuronal excitability in rat offspring. METHODS: We exposed dams to 1-BP (700 ppm, 6 h a day for 20 days) and examined hippocampal slices obtained from the male offspring at 2, 5, 8, and 13 weeks of age. We measured the stimulation/response (S/R) relationship and paired-pulse ratios (PPRs) of the population spike (PS) at the interpulse intervals (IPIs) of 5 and 10 ms in the CA1 subfield. RESULTS: Prenatal 1-BP exposure enhanced S/R relationships of PS at 2 weeks of age; however, the enhancement diminished at 5 weeks of age until it reached control levels. Prenatal 1-BP exposure decreased PPRs of PS at 2 weeks of age. After sexual maturation, however, the PPRs of PS increased at 5-ms IPI in rats aged 8 and 13 weeks. CONCLUSIONS: Our findings indicate that prenatal 1-BP exposure in dams can cause delayed adverse effects on excitability of pyramidal cells in the hippocampal CA1 subfield of offspring. Japan Society for Occupational Health 2017-11-01 2018-01-20 /pmc/articles/PMC5799103/ /pubmed/29093363 http://dx.doi.org/10.1539/joh.17-0009-BR Text en https://creativecommons.org/licenses/by-nc-sa/4.0/ Journal of Occupational Health is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Report
Fueta, Yukiko
Ishidao, Toru
Ueno, Susumu
Yoshida, Yasuhiro
Kanda, Yasunari
Hori, Hajime
Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title_full Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title_fullStr Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title_full_unstemmed Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title_short Prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the CA1 subfield of rat offspring
title_sort prenatal exposure to 1-bromopropane causes delayed adverse effects on hippocampal neuronal excitability in the ca1 subfield of rat offspring
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799103/
https://www.ncbi.nlm.nih.gov/pubmed/29093363
http://dx.doi.org/10.1539/joh.17-0009-BR
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