Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanis...

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Autores principales: Tang, Juan, Lin, Guoxin, Langdon, Wallace Y., Tao, Lijian, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799234/
https://www.ncbi.nlm.nih.gov/pubmed/29449845
http://dx.doi.org/10.3389/fimmu.2018.00123
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author Tang, Juan
Lin, Guoxin
Langdon, Wallace Y.
Tao, Lijian
Zhang, Jian
author_facet Tang, Juan
Lin, Guoxin
Langdon, Wallace Y.
Tao, Lijian
Zhang, Jian
author_sort Tang, Juan
collection PubMed
description Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.
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spelling pubmed-57992342018-02-15 Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity Tang, Juan Lin, Guoxin Langdon, Wallace Y. Tao, Lijian Zhang, Jian Front Immunol Immunology Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system. Frontiers Media S.A. 2018-02-01 /pmc/articles/PMC5799234/ /pubmed/29449845 http://dx.doi.org/10.3389/fimmu.2018.00123 Text en Copyright © 2018 Tang, Lin, Langdon, Tao and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tang, Juan
Lin, Guoxin
Langdon, Wallace Y.
Tao, Lijian
Zhang, Jian
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title_full Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title_fullStr Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title_full_unstemmed Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title_short Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
title_sort regulation of c-type lectin receptor-mediated antifungal immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799234/
https://www.ncbi.nlm.nih.gov/pubmed/29449845
http://dx.doi.org/10.3389/fimmu.2018.00123
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