miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition

Tumor metastasis is one of the main causes of hepatocellular carcinoma (HCC) high mortality. CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) play important roles in tumor metastasis, however, the exact role and underlying mechanism of CRKL in HCC is still unknown. In our study, we de...

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Detalles Bibliográficos
Autores principales: Guo, Chunmei, Zhao, Dongting, Zhang, Qiuling, Liu, Shuqing, Sun, Ming-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799248/
https://www.ncbi.nlm.nih.gov/pubmed/29403024
http://dx.doi.org/10.1038/s41598-018-20258-8

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