Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

Unraveling the mechanism of action and molecular target of small molecules remains a major challenge in drug discovery. While many cancer drugs target genetic vulnerabilities, loss-of-function screens fail to identify essential genes in drug mechanism of action. Here, we report CRISPRres, a CRISPR-C...

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Detalles Bibliográficos
Autores principales: Neggers, Jasper Edgar, Kwanten, Bert, Dierckx, Tim, Noguchi, Hiroki, Voet, Arnout, Bral, Lotte, Minner, Kristien, Massant, Bob, Kint, Nicolas, Delforge, Michel, Vercruysse, Thomas, Baloglu, Erkan, Senapedis, William, Jacquemyn, Maarten, Daelemans, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799254/
https://www.ncbi.nlm.nih.gov/pubmed/29402884
http://dx.doi.org/10.1038/s41467-017-02349-8

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