Primary growth hormone insensitivity and psychomotor delay

We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF‐1 axis should be perform...

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Detalles Bibliográficos
Autores principales: Castilla‐Cortazar, Inma, De Ita, Julieta Rodríguez, Aguirre, Gabriel A., Rodríguez‐Rivera, Joel, García‐Magariño, Mariano, Martín‐Estal, Irene, Flores‐Caloca, Óscar, Diaz‐Olachea, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799629/
https://www.ncbi.nlm.nih.gov/pubmed/29445490
http://dx.doi.org/10.1002/ccr3.1349
Descripción
Sumario:We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF‐1 axis should be performed in these cases to improve diagnosis and therapy.

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