Primary growth hormone insensitivity and psychomotor delay

We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF‐1 axis should be perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Castilla‐Cortazar, Inma, De Ita, Julieta Rodríguez, Aguirre, Gabriel A., Rodríguez‐Rivera, Joel, García‐Magariño, Mariano, Martín‐Estal, Irene, Flores‐Caloca, Óscar, Diaz‐Olachea, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799629/
https://www.ncbi.nlm.nih.gov/pubmed/29445490
http://dx.doi.org/10.1002/ccr3.1349
_version_ 1783298038519824384
author Castilla‐Cortazar, Inma
De Ita, Julieta Rodríguez
Aguirre, Gabriel A.
Rodríguez‐Rivera, Joel
García‐Magariño, Mariano
Martín‐Estal, Irene
Flores‐Caloca, Óscar
Diaz‐Olachea, Carlos
author_facet Castilla‐Cortazar, Inma
De Ita, Julieta Rodríguez
Aguirre, Gabriel A.
Rodríguez‐Rivera, Joel
García‐Magariño, Mariano
Martín‐Estal, Irene
Flores‐Caloca, Óscar
Diaz‐Olachea, Carlos
author_sort Castilla‐Cortazar, Inma
collection PubMed
description We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF‐1 axis should be performed in these cases to improve diagnosis and therapy.
format Online
Article
Text
id pubmed-5799629
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-57996292018-02-14 Primary growth hormone insensitivity and psychomotor delay Castilla‐Cortazar, Inma De Ita, Julieta Rodríguez Aguirre, Gabriel A. Rodríguez‐Rivera, Joel García‐Magariño, Mariano Martín‐Estal, Irene Flores‐Caloca, Óscar Diaz‐Olachea, Carlos Clin Case Rep Case Reports We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF‐1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF‐1 axis should be performed in these cases to improve diagnosis and therapy. John Wiley and Sons Inc. 2018-01-18 /pmc/articles/PMC5799629/ /pubmed/29445490 http://dx.doi.org/10.1002/ccr3.1349 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Castilla‐Cortazar, Inma
De Ita, Julieta Rodríguez
Aguirre, Gabriel A.
Rodríguez‐Rivera, Joel
García‐Magariño, Mariano
Martín‐Estal, Irene
Flores‐Caloca, Óscar
Diaz‐Olachea, Carlos
Primary growth hormone insensitivity and psychomotor delay
title Primary growth hormone insensitivity and psychomotor delay
title_full Primary growth hormone insensitivity and psychomotor delay
title_fullStr Primary growth hormone insensitivity and psychomotor delay
title_full_unstemmed Primary growth hormone insensitivity and psychomotor delay
title_short Primary growth hormone insensitivity and psychomotor delay
title_sort primary growth hormone insensitivity and psychomotor delay
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799629/
https://www.ncbi.nlm.nih.gov/pubmed/29445490
http://dx.doi.org/10.1002/ccr3.1349
work_keys_str_mv AT castillacortazarinma primarygrowthhormoneinsensitivityandpsychomotordelay
AT deitajulietarodriguez primarygrowthhormoneinsensitivityandpsychomotordelay
AT aguirregabriela primarygrowthhormoneinsensitivityandpsychomotordelay
AT rodriguezriverajoel primarygrowthhormoneinsensitivityandpsychomotordelay
AT garciamagarinomariano primarygrowthhormoneinsensitivityandpsychomotordelay
AT martinestalirene primarygrowthhormoneinsensitivityandpsychomotordelay
AT florescalocaoscar primarygrowthhormoneinsensitivityandpsychomotordelay
AT diazolacheacarlos primarygrowthhormoneinsensitivityandpsychomotordelay

Ejemplares similares