Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidi...

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Detalles Bibliográficos
Autores principales: Ribeiro Filho, Helder Veras, Bernardi Videira, Natália, Bridi, Aline Villanova, Tittanegro, Thais Helena, Helena Batista, Fernanda Aparecida, de Carvalho Pereira, José Geraldo, de Oliveira, Paulo Sérgio Lopes, Bajgelman, Marcio Chaim, Le Maire, Albane, Figueira, Ana Carolina Migliorini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799700/
https://www.ncbi.nlm.nih.gov/pubmed/29449830
http://dx.doi.org/10.3389/fendo.2018.00011

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