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Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among...

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Autores principales: Fernandez, Renae C, Moore, Vivienne M, Van Ryswyk, Emer M, Varcoe, Tamara J, Rodgers, Raymond J, March, Wendy A, Moran, Lisa J, Avery, Jodie C, McEvoy, R Doug, Davies, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799701/
https://www.ncbi.nlm.nih.gov/pubmed/29440941
http://dx.doi.org/10.2147/NSS.S127475
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author Fernandez, Renae C
Moore, Vivienne M
Van Ryswyk, Emer M
Varcoe, Tamara J
Rodgers, Raymond J
March, Wendy A
Moran, Lisa J
Avery, Jodie C
McEvoy, R Doug
Davies, Michael J
author_facet Fernandez, Renae C
Moore, Vivienne M
Van Ryswyk, Emer M
Varcoe, Tamara J
Rodgers, Raymond J
March, Wendy A
Moran, Lisa J
Avery, Jodie C
McEvoy, R Doug
Davies, Michael J
author_sort Fernandez, Renae C
collection PubMed
description Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight. There are several, possibly bidirectional, pathways through which PCOS is associated with sleep disturbances. The pathophysiology of PCOS involves hyperandrogenemia, a form of insulin resistance unique to affected women, and possible changes in cortisol and melatonin secretion, arguably reflecting altered hypothalamic–pituitary–adrenal function. Psychological and behavioral pathways are also likely to play a role, as anxiety and depression, smoking, alcohol use and lack of physical activity are also common among women with PCOS, partly in response to the distressing symptoms they experience. The specific impact of sleep disturbances on the health of women with PCOS is not yet clear; however, both PCOS and sleep disturbances are associated with deterioration in cardiometabolic health in the longer term and increased risk of type 2 diabetes. Both immediate quality of life and longer-term health of women with PCOS are likely to benefit from diagnosis and management of sleep disorders as part of interdisciplinary health care.
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spelling pubmed-57997012018-02-13 Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies Fernandez, Renae C Moore, Vivienne M Van Ryswyk, Emer M Varcoe, Tamara J Rodgers, Raymond J March, Wendy A Moran, Lisa J Avery, Jodie C McEvoy, R Doug Davies, Michael J Nat Sci Sleep Review Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight. There are several, possibly bidirectional, pathways through which PCOS is associated with sleep disturbances. The pathophysiology of PCOS involves hyperandrogenemia, a form of insulin resistance unique to affected women, and possible changes in cortisol and melatonin secretion, arguably reflecting altered hypothalamic–pituitary–adrenal function. Psychological and behavioral pathways are also likely to play a role, as anxiety and depression, smoking, alcohol use and lack of physical activity are also common among women with PCOS, partly in response to the distressing symptoms they experience. The specific impact of sleep disturbances on the health of women with PCOS is not yet clear; however, both PCOS and sleep disturbances are associated with deterioration in cardiometabolic health in the longer term and increased risk of type 2 diabetes. Both immediate quality of life and longer-term health of women with PCOS are likely to benefit from diagnosis and management of sleep disorders as part of interdisciplinary health care. Dove Medical Press 2018-02-01 /pmc/articles/PMC5799701/ /pubmed/29440941 http://dx.doi.org/10.2147/NSS.S127475 Text en © 2018 Fernandez et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Fernandez, Renae C
Moore, Vivienne M
Van Ryswyk, Emer M
Varcoe, Tamara J
Rodgers, Raymond J
March, Wendy A
Moran, Lisa J
Avery, Jodie C
McEvoy, R Doug
Davies, Michael J
Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_full Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_fullStr Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_full_unstemmed Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_short Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
title_sort sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799701/
https://www.ncbi.nlm.nih.gov/pubmed/29440941
http://dx.doi.org/10.2147/NSS.S127475
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