Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression

Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal...

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Detalles Bibliográficos
Autores principales: Di Ruocco, F, Basso, V, Rivoire, M, Mehlen, P, Ambati, J, De Falco, S, Tarallo, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799714/
https://www.ncbi.nlm.nih.gov/pubmed/28991230
http://dx.doi.org/10.1038/onc.2017.369

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