A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) associated with cancer promotion, in this case lung...

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Detalles Bibliográficos
Autores principales: Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J, Waters, M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799715/
https://www.ncbi.nlm.nih.gov/pubmed/28967904
http://dx.doi.org/10.1038/onc.2017.352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799715/
https://www.ncbi.nlm.nih.gov/pubmed/28967904
http://dx.doi.org/10.1038/onc.2017.352

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