AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11

Deregulated AKT kinase activity due to PTEN deficiency in cancer cells contributes to oncogenesis by incompletely understood mechanisms. Here, we show that PTEN deletion in HCT116 and DLD1 colon carcinoma cells leads to suppression of CHK1 and CHK2 activation in response to irradiation, impaired G2...

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Detalles Bibliográficos
Autores principales: Piscitello, D, Varshney, D, Lilla, S, Vizioli, M G, Reid, C, Gorbunova, V, Seluanov, A, Gillespie, D A, Adams, P D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799716/
https://www.ncbi.nlm.nih.gov/pubmed/28967905
http://dx.doi.org/10.1038/onc.2017.340

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