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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, c...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Termedia Publishing House
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799752/ https://www.ncbi.nlm.nih.gov/pubmed/29422815 http://dx.doi.org/10.5114/pdia.2017.67053 |
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| author | Nedoszytko, Bogusław Sokołowska-Wojdyło, Małgorzata Renke, Joanna Lange, Magdalena Trzonkowski, Piotr Sobjanek, Michał Szczerkowska-Dobosz, Aneta Niedoszytko, Marek Górska, Aleksandra Romantowski, Jan Skokowski, Jarosław Kalinowski, Leszek Nowicki, Roman J |
| author_facet | Nedoszytko, Bogusław Sokołowska-Wojdyło, Małgorzata Renke, Joanna Lange, Magdalena Trzonkowski, Piotr Sobjanek, Michał Szczerkowska-Dobosz, Aneta Niedoszytko, Marek Górska, Aleksandra Romantowski, Jan Skokowski, Jarosław Kalinowski, Leszek Nowicki, Roman J |
| author_sort | Nedoszytko, Bogusław |
| collection | PubMed |
| description | Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases. |
| format | Online Article Text |
| id | pubmed-5799752 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Termedia Publishing House |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57997522018-02-08 The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function Nedoszytko, Bogusław Sokołowska-Wojdyło, Małgorzata Renke, Joanna Lange, Magdalena Trzonkowski, Piotr Sobjanek, Michał Szczerkowska-Dobosz, Aneta Niedoszytko, Marek Górska, Aleksandra Romantowski, Jan Skokowski, Jarosław Kalinowski, Leszek Nowicki, Roman J Postepy Dermatol Alergol Review Paper Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases. Termedia Publishing House 2017-12-31 2017-12 /pmc/articles/PMC5799752/ /pubmed/29422815 http://dx.doi.org/10.5114/pdia.2017.67053 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
| spellingShingle | Review Paper Nedoszytko, Bogusław Sokołowska-Wojdyło, Małgorzata Renke, Joanna Lange, Magdalena Trzonkowski, Piotr Sobjanek, Michał Szczerkowska-Dobosz, Aneta Niedoszytko, Marek Górska, Aleksandra Romantowski, Jan Skokowski, Jarosław Kalinowski, Leszek Nowicki, Roman J The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title | The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title_full | The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title_fullStr | The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title_full_unstemmed | The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title_short | The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function |
| title_sort | role of regulatory t cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. part iii: polymorphisms of genes involved in tregs’ activation and function |
| topic | Review Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799752/ https://www.ncbi.nlm.nih.gov/pubmed/29422815 http://dx.doi.org/10.5114/pdia.2017.67053 |
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