Cargando…

PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis

Phosphatidylinositol 3-kinase (PI3K) signaling plays an important role in the regulation of cellular lipid metabolism and non-alcoholic fatty liver disease (NAFLD). However, little is known about the role of the regulatory subunits of PI3K in lipid metabolism and NAFLD. In this study, we characteriz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xi, Fu, Yinjia, Hu, Fuqing, Luo, Xuelai, Hu, Junbo, Wang, Guihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799801/ https://www.ncbi.nlm.nih.gov/pubmed/29350678 http://dx.doi.org/10.1038/emm.2017.243

Ejemplares similares

Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
por: Wang, Guihua, et al.
Publicado: (2017)

Correction: Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
por: Wang, Guihua, et al.
Publicado: (2021)

KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors
por: Lai, Senyan, et al.
Publicado: (2015)

PIK3R3 inhibits cell senescence through p53/p21 signaling
por: Chen, Qianzhi, et al.
Publicado: (2020)

Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway
por: Hu, Fuqing, et al.
Publicado: (2018)

p55PIK Transcriptionally Activated by MZF1 Promotes Colorectal Cancer Cell Proliferation
por: Deng, Yu, et al.
Publicado: (2013)

The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation
por: Hu, Fuqing, et al.
Publicado: (2020)

SIX4 promotes metastasis via activation of the PI3K-AKT pathway in colorectal cancer
por: Li, Guodong, et al.
Publicado: (2017)

Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice
por: Ramdhan, Doni Hikmat, et al.
Publicado: (2010)

Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling
por: Hu, Fuqing, et al.
Publicado: (2018)

Correction to: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling
por: Hu, Fuqing, et al.
Publicado: (2018)

A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis
por: Cho, Bennet S., et al.
Publicado: (2023)

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling
por: Hou, Zhenlin, et al.
Publicado: (2018)

Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36
por: Rey, Esther, et al.
Publicado: (2020)

EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis
por: Huang, Changsheng, et al.
Publicado: (2022)

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
por: Mazloumi Gavgani, Fatemeh, et al.
Publicado: (2018)

Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library
por: Zhou, Jin, et al.
Publicado: (2012)

KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer
por: Li, Haijie, et al.
Publicado: (2016)

Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling
por: Zhao, Jiejie, et al.
Publicado: (2018)

KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation
por: Li, Haijie, et al.
Publicado: (2020)

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα
por: Nakagawa, Yoshimi, et al.
Publicado: (2016)

Ceramides: Nutrient Signals that Drive Hepatosteatosis
por: Summers, Scott A.
Publicado: (2020)

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors
por: Liu, Yane, et al.
Publicado: (2022)

A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice
por: Lloyd, David J., et al.
Publicado: (2010)

Right ventricular function and its relationship with grade of hepatosteatosis in non-alcoholic fatty liver disease
por: Bekler, Adem, et al.
Publicado: (2015)

Fatty acid binding protein-4 promotes alcohol-dependent hepatosteatosis and hepatocellular carcinoma progression
por: Attal, Neha, et al.
Publicado: (2020)

BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer
por: Zhu, Xu, et al.
Publicado: (2016)

LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression
por: Zhang, Tianpeng, et al.
Publicado: (2019)

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
por: Chen, Li, et al.
Publicado: (2018)

Adipocyte-derived Periostin mediates glucocorticoid-induced hepatosteatosis in mice
por: Wan, Jian, et al.
Publicado: (2019)

PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
por: Zhang, Wenjie, et al.
Publicado: (2015)

Hepatosteatosis from Lysosomal Acid Lipase Deficiency
por: Zandanell, Stephan, et al.
Publicado: (2018)

Role of hepatosteatosis in the prognosis of COVID 19 disease
por: Çoraplı, Mahmut, et al.
Publicado: (2021)

Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis
por: Chen, Yulian, et al.
Publicado: (2023)

Detection of Impaired Cognitive Function in Rat with Hepatosteatosis Model and Improving Effect of GLP-1 Analogs (Exenatide) on Cognitive Function in Hepatosteatosis
por: Erbaş, Oytun, et al.
Publicado: (2014)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met
por: Cao, Xiaonian, et al.
Publicado: (2017)

Carcinogenesis of PIK3CA
por: German, Sidra, et al.
Publicado: (2013)

Omega-3 Fatty Acids and PPARγ in Cancer
por: Edwards, Iris J., et al.
Publicado: (2008)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion
por: van Zwol, Willemien, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tapkbmr4seanaj2r3dvtdfi0bq