Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy

BACKGROUND: An extensive crosstalk co-regulates the Hippo and Wnt pathway. Preclinical studies revealed that the Hippo transducers YAP/TAZ mediate a number of oncogenic functions in gastric cancer (GC). Moreover, comprehensive characterization of GC demonstrated that the Wnt pathway is targeted by o...

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Detalles Bibliográficos
Autores principales: Melucci, Elisa, Casini, Beatrice, Ronchetti, Livia, Pizzuti, Laura, Sperati, Francesca, Pallocca, Matteo, De Nicola, Francesca, Goeman, Frauke, Gallo, Enzo, Amoreo, Carla Azzurra, Sergi, Domenico, Terrenato, Irene, Vici, Patrizia, Di Lauro, Luigi, Diodoro, Maria Grazia, Pescarmona, Edoardo, Barba, Maddalena, Mazzotta, Marco, Mottolese, Marcella, Fanciulli, Maurizio, Ciliberto, Gennaro, De Maria, Ruggero, Buglioni, Simonetta, Maugeri-Saccà, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800016/
https://www.ncbi.nlm.nih.gov/pubmed/29402328
http://dx.doi.org/10.1186/s12967-018-1385-y

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