Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy

Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients’ death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-inte...

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Autor principal: Halder, Umesh Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800069/
https://www.ncbi.nlm.nih.gov/pubmed/29445623
http://dx.doi.org/10.1186/s40709-018-0075-5
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author Halder, Umesh Chandra
author_facet Halder, Umesh Chandra
author_sort Halder, Umesh Chandra
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description Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients’ death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect.
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spelling pubmed-58000692018-02-14 Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy Halder, Umesh Chandra J Biol Res (Thessalon) Hypothesis Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients’ death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect. BioMed Central 2018-02-05 /pmc/articles/PMC5800069/ /pubmed/29445623 http://dx.doi.org/10.1186/s40709-018-0075-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Hypothesis
Halder, Umesh Chandra
Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title_full Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title_fullStr Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title_full_unstemmed Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title_short Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
title_sort bone marrow stem cells to destroy circulating hiv: a hypothetical therapeutic strategy
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800069/
https://www.ncbi.nlm.nih.gov/pubmed/29445623
http://dx.doi.org/10.1186/s40709-018-0075-5
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