Cargando…

Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakkiah, Sugunadevi, Wang, Tony, Zou, Wen, Wang, Yuping, Pan, Bohu, Tong, Weida, Hong, Huixiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800125/
https://www.ncbi.nlm.nih.gov/pubmed/29295509
http://dx.doi.org/10.3390/ijerph15010025
_version_ 1783298147002351616
author Sakkiah, Sugunadevi
Wang, Tony
Zou, Wen
Wang, Yuping
Pan, Bohu
Tong, Weida
Hong, Huixiao
author_facet Sakkiah, Sugunadevi
Wang, Tony
Zou, Wen
Wang, Yuping
Pan, Bohu
Tong, Weida
Hong, Huixiao
author_sort Sakkiah, Sugunadevi
collection PubMed
description Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus.
format Online
Article
Text
id pubmed-5800125
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58001252018-02-06 Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus Sakkiah, Sugunadevi Wang, Tony Zou, Wen Wang, Yuping Pan, Bohu Tong, Weida Hong, Huixiao Int J Environ Res Public Health Review Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus. MDPI 2017-12-23 2018-01 /pmc/articles/PMC5800125/ /pubmed/29295509 http://dx.doi.org/10.3390/ijerph15010025 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sakkiah, Sugunadevi
Wang, Tony
Zou, Wen
Wang, Yuping
Pan, Bohu
Tong, Weida
Hong, Huixiao
Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title_full Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title_fullStr Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title_full_unstemmed Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title_short Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
title_sort endocrine disrupting chemicals mediated through binding androgen receptor are associated with diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800125/
https://www.ncbi.nlm.nih.gov/pubmed/29295509
http://dx.doi.org/10.3390/ijerph15010025
work_keys_str_mv AT sakkiahsugunadevi endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT wangtony endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT zouwen endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT wangyuping endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT panbohu endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT tongweida endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus
AT honghuixiao endocrinedisruptingchemicalsmediatedthroughbindingandrogenreceptorareassociatedwithdiabetesmellitus