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Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk b...

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Autores principales: Minatoya, Machiko, Itoh, Sachiko, Araki, Atsuko, Tamura, Naomi, Yamazaki, Keiko, Miyashita, Chihiro, Kishi, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800219/
https://www.ncbi.nlm.nih.gov/pubmed/29324697
http://dx.doi.org/10.3390/ijerph15010120
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author Minatoya, Machiko
Itoh, Sachiko
Araki, Atsuko
Tamura, Naomi
Yamazaki, Keiko
Miyashita, Chihiro
Kishi, Reiko
author_facet Minatoya, Machiko
Itoh, Sachiko
Araki, Atsuko
Tamura, Naomi
Yamazaki, Keiko
Miyashita, Chihiro
Kishi, Reiko
author_sort Minatoya, Machiko
collection PubMed
description Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age.
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spelling pubmed-58002192018-02-06 Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health Minatoya, Machiko Itoh, Sachiko Araki, Atsuko Tamura, Naomi Yamazaki, Keiko Miyashita, Chihiro Kishi, Reiko Int J Environ Res Public Health Article Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age. MDPI 2018-01-11 2018-01 /pmc/articles/PMC5800219/ /pubmed/29324697 http://dx.doi.org/10.3390/ijerph15010120 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Minatoya, Machiko
Itoh, Sachiko
Araki, Atsuko
Tamura, Naomi
Yamazaki, Keiko
Miyashita, Chihiro
Kishi, Reiko
Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title_full Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title_fullStr Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title_full_unstemmed Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title_short Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health
title_sort association between fetal adipokines and child behavioral problems at preschool age: the hokkaido study on environment and children’s health
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800219/
https://www.ncbi.nlm.nih.gov/pubmed/29324697
http://dx.doi.org/10.3390/ijerph15010120
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