Cargando…
Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing
Epidemiology studies indicated that air pollution has been associated with adverse neurological effects in human. Moreover, the secretion of glucocorticoid (GC) affects the mood regulation, and the negative feedback of hippocampal glucocorticoid receptors (GR) inhibits the GC secretion. Meanwhile, t...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800259/ https://www.ncbi.nlm.nih.gov/pubmed/29351245 http://dx.doi.org/10.3390/ijerph15010160 |
_version_ | 1783298178566586368 |
---|---|
author | Jia, Zhen Wei, Yongjie Li, Xiaoqian Yang, Lixin Liu, Huijie Guo, Chen Zhang, Lulu Li, Nannan Guo, Shaojuan Qian, Yan Li, Zhigang |
author_facet | Jia, Zhen Wei, Yongjie Li, Xiaoqian Yang, Lixin Liu, Huijie Guo, Chen Zhang, Lulu Li, Nannan Guo, Shaojuan Qian, Yan Li, Zhigang |
author_sort | Jia, Zhen |
collection | PubMed |
description | Epidemiology studies indicated that air pollution has been associated with adverse neurological effects in human. Moreover, the secretion of glucocorticoid (GC) affects the mood regulation, and the negative feedback of hippocampal glucocorticoid receptors (GR) inhibits the GC secretion. Meanwhile, the over secretion of GC can interfere the immune system and induce neurotoxicity. In the present study, the human test showed that the secretion of the cortisol in plasma was elevated after exposure in heavy air pollution. In the mouse model, we found that breathing the highly polluted air resulted in the negative responses of the mood-related behavioral tests and morphology of hippocampus, as well as the over secretion of GC in plasma, down regulation of GR, and up-regulation of cytokine and chemokine in the hippocampus. When considering the interrelated trends between the hippocampal GR, inflammatory factors, and plasmatic GC, we speculated that PM(2.5) exposure could lead to the increased secretion of GC in plasma by decreasing the expression of GR in hippocampus, which activated the inflammation response, and finally induced neurotoxicity, suggesting that PM(2.5) exposure negatively affects mood regulation. When combined with the results of the human test, it indicated that exposure to ambient air particles increased the risk of mental disorder. |
format | Online Article Text |
id | pubmed-5800259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58002592018-02-06 Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing Jia, Zhen Wei, Yongjie Li, Xiaoqian Yang, Lixin Liu, Huijie Guo, Chen Zhang, Lulu Li, Nannan Guo, Shaojuan Qian, Yan Li, Zhigang Int J Environ Res Public Health Article Epidemiology studies indicated that air pollution has been associated with adverse neurological effects in human. Moreover, the secretion of glucocorticoid (GC) affects the mood regulation, and the negative feedback of hippocampal glucocorticoid receptors (GR) inhibits the GC secretion. Meanwhile, the over secretion of GC can interfere the immune system and induce neurotoxicity. In the present study, the human test showed that the secretion of the cortisol in plasma was elevated after exposure in heavy air pollution. In the mouse model, we found that breathing the highly polluted air resulted in the negative responses of the mood-related behavioral tests and morphology of hippocampus, as well as the over secretion of GC in plasma, down regulation of GR, and up-regulation of cytokine and chemokine in the hippocampus. When considering the interrelated trends between the hippocampal GR, inflammatory factors, and plasmatic GC, we speculated that PM(2.5) exposure could lead to the increased secretion of GC in plasma by decreasing the expression of GR in hippocampus, which activated the inflammation response, and finally induced neurotoxicity, suggesting that PM(2.5) exposure negatively affects mood regulation. When combined with the results of the human test, it indicated that exposure to ambient air particles increased the risk of mental disorder. MDPI 2018-01-19 2018-01 /pmc/articles/PMC5800259/ /pubmed/29351245 http://dx.doi.org/10.3390/ijerph15010160 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jia, Zhen Wei, Yongjie Li, Xiaoqian Yang, Lixin Liu, Huijie Guo, Chen Zhang, Lulu Li, Nannan Guo, Shaojuan Qian, Yan Li, Zhigang Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title | Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title_full | Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title_fullStr | Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title_full_unstemmed | Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title_short | Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing |
title_sort | exposure to ambient air particles increases the risk of mental disorder: findings from a natural experiment in beijing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800259/ https://www.ncbi.nlm.nih.gov/pubmed/29351245 http://dx.doi.org/10.3390/ijerph15010160 |
work_keys_str_mv | AT jiazhen exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT weiyongjie exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT lixiaoqian exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT yanglixin exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT liuhuijie exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT guochen exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT zhanglulu exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT linannan exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT guoshaojuan exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT qianyan exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing AT lizhigang exposuretoambientairparticlesincreasestheriskofmentaldisorderfindingsfromanaturalexperimentinbeijing |